Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.

by Yilin Cao, Jeffrey C Rathmell, Andrew N Macintyre
Published 2014-01-01

The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

by Aaron R Lim, W Kimryn Rathmell, Jeffrey C Rathmell
Published 2020-05-01

HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

by Alexandra Arreola, C Lance Cowey, Jonathan L Coloff, Jeffrey C Rathmell, W Kimryn Rathmell
Published 2014-01-01

Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response

by Venkataswarup Tiriveedhi, Michael T. Ivy, Elbert L. Myles, Roy Zent, Jeffrey C. Rathmell, Jens Titze
Published 2021-04-01

Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

by Stephanie O. Dudzinski, Brent D. Cameron, Jian Wang, Jeffrey C. Rathmell, Todd D. Giorgio, Austin N. Kirschner
Published 2019-08-01

Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses agai...

by Duaa Babaer, Suneetha Amara, Brenda S. McAdory, Owen Johnson, Elbert L. Myles, Roy Zent, Jeffrey C. Rathmell, Venkataswarup Tiriveedhi
Published 2019-05-01

MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy

by Stephanie Dudzinski, Kathryn E Beckermann, Kirsten Young, Eliot McKinley, Oliver J McIntyre, Jeffrey C Rathmell, Junzhong Xu, John C Gore
Published 2020-06-01

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

by Hubaida Fuseini, Jacqueline-Yvonne Cephus, Pingsheng Wu, J. Brooke Davis, Diana C. Contreras, Vivek D. Gandhi, Jeffrey C. Rathmell, Dawn C. Newcomb, Dawn C. Newcomb
Published 2019-11-01

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway

by Yen-Hua Chen, Radomir Kratchmarov, Wen-Hsuan W. Lin, Nyanza J. Rothman, Bonnie Yen, William C. Adams, Simone A. Nish, Jeffrey C. Rathmell, Steven L. Reiner
Published 2018-01-01

Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling

by Peter J. Siska, Romany A. N. Johnpulle, Alice Zhou, Jennifer Bordeaux, Ju Young Kim, Bashar Dabbas, Naveen Dakappagari, Jeffrey C. Rathmell, W. Kimryn Rathmell, Alicia K. Morgans, Justin M. Balko, Douglas B. Johnson
Published 2017-04-01

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

by Sunghee Park, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, Tingyu Liu, Jeffrey C. Rathmell, Mark W. Dewhirst, Kris C. Wood, Jason W. Locasale, Donald P. McDonnell
Published 2016-04-01

Antigen receptor control of methionine metabolism in T cells

by Linda V Sinclair, Andrew JM Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Published 2019-03-01

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal

by William C. Adams, Yen-Hua Chen, Radomir Kratchmarov, Bonnie Yen, Simone A. Nish, Wen-Hsuan W. Lin, Nyanza J. Rothman, Larry L. Luchsinger, Ulf Klein, Meinrad Busslinger, Jeffrey C. Rathmell, Hans-Willem Snoeck, Steven L. Reiner
Published 2016-12-01

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation

by Kathryn E. Beckermann, Rachel Hongo, Xiang Ye, Kirsten Young, Katie Carbonell, Diana C. Contreras Healey, Peter J. Siska, Sierra Barone, Caroline E. Roe, Christof C. Smith, Benjamin G. Vincent, Frank M. Mason, Jonathan M. Irish, W. Kimryn Rathmell, Jeffrey C. Rathmell
Published 2020-08-01

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

by Caroline Contat, Pierre-Benoit Ancey, Nadine Zangger, Silvia Sabatino, Justine Pascual, Stéphane Escrig, Louise Jensen, Christine Goepfert, Bernard Lanz, Mario Lepore, Rolf Gruetter, Anouk Rossier, Sabina Berezowska, Christina Neppl, Inti Zlobec, Stéphanie Clerc-Rosset, Graham William Knott, Jeffrey C Rathmell, E Dale Abel, Anders Meibom, Etienne Meylan
Published 2020-06-01

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

by Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Michelle Demory Beckler, Emily J. Poulin, Alex J. Walsh, Melissa C. Skala, Eliot T. McKinley, H. Charles Manning, Matthew R. Hight, Michael L. Schulte, Kimberly R. Watt, G. Daniel Ayers, Melissa M. Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Jeffrey L. Franklin, Robert J. Coffey
Published 2018-01-01

Clinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma

by Eileen Shiuan, Anupama Reddy, Stephanie O. Dudzinski, Aaron R. Lim, Ayaka Sugiura, Rachel Hongo, Kirsten Young, Xian-De Liu, Christof C. Smith, Jamye O’Neal, Kimberly B. Dahlman, Renee McAlister, Beiru Chen, Kristen Ruma, Nathan Roscoe, Jehovana Bender, Joolz Ward, Ju Young Kim, Christine Vaupel, Jennifer Bordeaux, Shridar Ganesan, Tina M. Mayer, Gregory M. Riedlinger, Benjamin G. Vincent, Nancy B. Davis, Scott M. Haake, Jeffrey C. Rathmell, Eric Jonasch, Brian I. Rini, W. Kimryn Rathmell, Kathryn E. Beckermann
Published 2021-03-01