Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer

by Dmitriy Zamarin, Jedd D Wolchok
Published 2014-01-01

CTLA-4 and PD-1 pathway Blockade : Combinations in the Clinic

by Margaret Kathleen Callahan, Margaret Kathleen Callahan, Michael A Postow, Michael A Postow, Jedd D Wolchok, Jedd D Wolchok, Jedd D Wolchok
Published 2015-01-01

Progressive choroidal thinning (leptochoroid) and fundus depigmentation associated with checkpoint inhibitors

by Julia Canestraro, Korey A. Jaben, Jedd D. Wolchok, David H. Abramson, Jasmine H. Francis
Published 2020-09-01

Melanoma brain metastases treated with stereotactic radiosurgery and concurrent pembrolizumab display marked regression; efficacy and safety of combined treatment

by Erik S. Anderson, Michael A. Postow, Jedd D. Wolchok, Robert J. Young, Åse Ballangrud, Timothy A. Chan, Yoshiya Yamada, Kathryn Beal
Published 2017-10-01

Neutrophil to Lymphocyte Ratio is Associated With Outcome During Ipilimumab Treatment

by Michael R. Cassidy, Rachel E. Wolchok, Junting Zheng, Katherine S. Panageas, Jedd D. Wolchok, Daniel Coit, Michael A. Postow, Charlotte Ariyan
Published 2017-04-01

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

by Rikke B. Holmgaard, Dmitriy Zamarin, Yanyun Li, Billel Gasmi, David H. Munn, James P. Allison, Taha Merghoub, Jedd D. Wolchok
Published 2015-10-01

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

by Dmitriy Zamarin, Rikke B. Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D. Wolchok, James P. Allison
Published 2017-02-01

Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity.

by Francesca Avogadri, Taha Merghoub, Maureen F Maughan, Daniel Hirschhorn-Cymerman, John Morris, Erika Ritter, Robert Olmsted, Alan N Houghton, Jedd D Wolchok
Published 2010-09-01

Acquired resistance to immunotherapy in MMR-D pancreatic cancer

by Zishuo Ian Hu, Matthew D. Hellmann, Jedd D. Wolchok, Monika Vyas, Jinru Shia, Zsofia K. Stadler, Luis A. Diaz, Eileen M. O’Reilly
Published 2018-11-01

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

by Krista Dubin, Margaret K. Callahan, Boyu Ren, Raya Khanin, Agnes Viale, Lilan Ling, Daniel No, Asia Gobourne, Eric Littmann, Curtis Huttenhower, Eric G. Pamer, Jedd D. Wolchok
Published 2016-02-01

Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer

by Souhil Lebdai, Mathieu Gigoux, Ricardo Alvim, Alexander Somma, Karan Nagar, Abdel Rahmene Azzouzi, Olivier Cussenot, Taha Merghoub, Jedd D. Wolchok, Avigdor Scherz, Kwanghee Kim, Jonathan Coleman
Published 2019-06-01

Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope.

by David A Schaer, Yongbiao Li, Taha Merghoub, Gabrielle A Rizzuto, Amos Shemesh, Adam D Cohen, Yanyun Li, Francesca Avogadri, Ricardo Toledo-Crow, Alan N Houghton, Jedd D Wolchok
Published 2011-01-01

Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.

by Maggie Eidson, Justin Wahlstrom, Aimee M Beaulieu, Bushra Zaidi, Steven E Carsons, Peggy K Crow, Jianda Yuan, Jedd D Wolchok, Bernhard Horsthemke, Dagmar Wieczorek, Derek B Sant'Angelo
Published 2011-01-01

Langerhans-type dendritic cells electroporated with TRP-2 mRNA stimulate cellular immunity against melanoma: Results of a phase I vaccine trial

by David J. Chung, Richard D. Carvajal, Michael A. Postow, Sneh Sharma, Katherine B. Pronschinske, Justin A. Shyer, Shahnaz Singh-Kandah, Mark A. Dickson, Sandra P. D'Angelo, Jedd D. Wolchok, James W. Young
Published 2018-01-01

Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.

by Adam D Cohen, David A Schaer, Cailian Liu, Yanyun Li, Daniel Hirschhorn-Cymmerman, Soo Chong Kim, Adi Diab, Gabrielle Rizzuto, Fei Duan, Miguel A Perales, Taha Merghoub, Alan N Houghton, Jedd D Wolchok
Published 2010-05-01

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

by Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Published 2019-04-01

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

by Sadna Budhu, Rachel Giese, Aditi Gupta, Kelly Fitzgerald, Roberta Zappasodi, Sara Schad, Daniel Hirschhorn, Luis Felipe Campesato, Olivier De Henau, Mathieu Gigoux, Cailian Liu, Gregory Mazo, Liang Deng, Christopher A. Barker, Jedd D. Wolchok, Taha Merghoub
Published 2021-01-01

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

by Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok
Published 2020-08-01

A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma

by Craig L. Slingluff, Hassane M. Zarour, Hussein Abdul-Hassan Tawbi, John M. Kirkwood, Michael A. Postow, Philip Friedlander, Craig E. Devoe, Elizabeth M. Gaughan, Ileana S. Mauldin, Walter C. Olson, Kelly T. Smith, Mary J. Macri, Toni Ricciardi, Aileen Ryan, Ralph Venhaus, Jedd D. Wolchok
Published 2021-01-01

Enhanced responses to tumor immunization following total body irradiation are time-dependent.

by Adi Diab, Robert R Jenq, Gabrielle A Rizzuto, Adam D Cohen, Deonka W Huggins, Taha Merghoub, Manuel E Engelhorn, José A Guevara-Patiño, David Suh, Vanessa M Hubbard-Lucey, Adam A Kochman, Suzie Chen, Hong Zhong, Jedd D Wolchok, Marcel R M van den Brink, Alan N Houghton, Miguel-Angel Perales
Published 2013-01-01