Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

by Jaigeeth Deveryshetty, Thibaut Peterlini, Mikhail Ryzhikov, Nadine Brahiti, Graham Dellaire, Jean-Yves Masson, Sergey Korolev
Published 2019-04-01

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism.

by Marie-Claude N Laffitte, Philippe Leprohon, Maripier Hainse, Danielle Légaré, Jean-Yves Masson, Marc Ouellette
Published 2016-06-01

Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease.

by Marie-Claude N Laffitte, Marie-Michelle Genois, Angana Mukherjee, Danielle Légaré, Jean-Yves Masson, Marc Ouellette
Published 2014-12-01

Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

by Rémi Buisson, Joshi Niraj, Joris Pauty, Ranjan Maity, Weixing Zhao, Yan Coulombe, Patrick Sung, Jean-Yves Masson
Published 2014-02-01

Molecular Determinant of DIDS Analogs Targeting RAD51 Activity

by Denis Velic, Alexandre Demeyer, Thibaut Peterlini, Houda Benhelli-Mokrani, Monique Mathé-Allainmat, Jean-Yves Masson, Fabrice Fleury
Published 2021-09-01

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

by Denis Velic, Anthony M. Couturier, Maria Tedim Ferreira, Amélie Rodrigue, Guy G. Poirier, Fabrice Fleury, Jean-Yves Masson
Published 2015-11-01

Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation

by Julia O’Sullivan, Maria Tedim Ferreira, Jean-Philippe Gagné, Ajit K. Sharma, Michael J. Hendzel, Jean-Yves Masson, Guy G. Poirier
Published 2019-03-01

A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development.

by Michèle Rouleau, Vishal Saxena, Amélie Rodrigue, Eric R Paquet, Abbie Gagnon, Michael J Hendzel, Jean-Yves Masson, Marc Ekker, Guy G Poirier
Published 2011-01-01

Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase in...

by Razan Sheta, Magdalena Bachvarova, Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire, Jamilet Miranda Navarro, Ricardo Bringas Perez, Jean-Yves Masson, Dimcho Bachvarov
Published 2020-11-01

The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.

by Veronica L Martinez-Marignac, Amélie Rodrigue, David Davidson, Martin Couillard, Ala-Eddin Al-Moustafa, Mark Abramovitz, William D Foulkes, Jean-Yves Masson, Raquel Aloyz
Published 2011-01-01

E4F1 Is a Master Regulator of CHK1-Mediated Functions

by David Grote, Céline Moison, Stéphanie Duhamel, Jalila Chagraoui, Simon Girard, Jay Yang, Nadine Mayotte, Yan Coulombe, Jean-Yves Masson, Grant W. Brown, Sylvain Meloche, Guy Sauvageau
Published 2015-04-01

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

by Martijn S Luijsterburg, Dimitris Typas, Marie-Christine Caron, Wouter W Wiegant, Diana van den Heuvel, Rick A Boonen, Anthony M Couturier, Leon H Mullenders, Jean-Yves Masson, Haico van Attikum
Published 2017-02-01

Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2

by Rick A. C. M. Boonen, Amélie Rodrigue, Chantal Stoepker, Wouter W. Wiegant, Bas Vroling, Milan Sharma, Magdalena B. Rother, Nandi Celosse, Maaike P. G. Vreeswijk, Fergus Couch, Jacques Simard, Peter Devilee, Jean-Yves Masson, Haico van Attikum
Published 2019-11-01

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

by Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Nadine Sen Nkwe, Daméhan Tchelougou, Maxime Uriarte, Eric Bonneil, Derek Ceccarelli, Nazar Mashtalir, Mika Tanji, Jean-Yves Masson, Pierre Thibault, Frank Sicheri, Haining Yang, Michele Carbone, Marc Therrien, El Bachir Affar
Published 2018-10-01

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

by Emily Yun-Chia Chang, Shuhe Tsai, Maria J. Aristizabal, James P. Wells, Yan Coulombe, Franciele F. Busatto, Yujia A. Chan, Arun Kumar, Yi Dan Zhu, Alan Ying-Hsu Wang, Louis-Alexandre Fournier, Philip Hieter, Michael S. Kobor, Jean-Yves Masson, Peter C. Stirling
Published 2019-09-01

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

by Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier, Jean-Yves Masson
Published 2019-07-01

ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.

by Anne-Laure Renault, Fabienne Lesueur, Yan Coulombe, Stéphane Gobeil, Penny Soucy, Yosr Hamdi, Sylvie Desjardins, Florence Le Calvez-Kelm, Maxime Vallée, Catherine Voegele, Breast Cancer Family Registry, John L Hopper, Irene L Andrulis, Melissa C Southey, Esther M John, Jean-Yves Masson, Sean V Tavtigian, Jacques Simard
Published 2016-01-01

ZNF768 links oncogenic RAS to cellular senescence

by Romain Villot, Audrey Poirier, Inan Bakan, Karine Boulay, Erlinda Fernández, Romain Devillers, Luciano Gama-Braga, Laura Tribouillard, Andréanne Gagné, Éma Duchesne, Danielle Caron, Jean-Sébastien Bérubé, Jean-Christophe Bérubé, Yan Coulombe, Michèle Orain, Yves Gélinas, Stéphane Gobeil, Yohan Bossé, Jean-Yves Masson, Sabine Elowe, Steve Bilodeau, Venkata Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Published 2021-08-01

Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I)

by Jennifer D. Brooks, Hermann H. Nabi, Irene L. Andrulis, Antonis C. Antoniou, Jocelyne Chiquette, Philippe Després, Peter Devilee, Michel Dorval, Arnaud Droit, Douglas F. Easton, Andrea Eisen, Laurence Eloy, Samantha Fienberg, David Goldgar, Eric Hahnen, Yann Joly, Bartha Maria Knoppers, Aisha Lofters, Jean-Yves Masson, Nicole Mittmann, Jean-Sébastien Paquette, Nora Pashayan, Rita Schmutzler, Tracy Stockley, Sean V. Tavtigian, Meghan J. Walker, Michael Wolfson, Anna Maria Chiarelli, Jacques Simard
Published 2021-06-01

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

by Marta Castroviejo‐Bermejo, Cristina Cruz, Alba Llop‐Guevara, Sara Gutiérrez‐Enríquez, Mandy Ducy, Yasir Hussein Ibrahim, Albert Gris‐Oliver, Benedetta Pellegrino, Alejandra Bruna, Marta Guzmán, Olga Rodríguez, Judit Grueso, Sandra Bonache, Alejandro Moles‐Fernández, Guillermo Villacampa, Cristina Viaplana, Patricia Gómez, Maria Vidal, Vicente Peg, Xavier Serres‐Créixams, Graham Dellaire, Jacques Simard, Paolo Nuciforo, Isabel T Rubio, Rodrigo Dienstmann, J Carl Barrett, Carlos Caldas, José Baselga, Cristina Saura, Javier Cortés, Olivier Déas, Jos Jonkers, Jean‐Yves Masson, Stefano Cairo, Jean‐Gabriel Judde, Mark J O'Connor, Orland Díez, Judith Balmaña, Violeta Serra
Published 2018-12-01