High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention.

by Ivanny Marchant, Jean-Pierre Boissel, Patrice Nony, François Gueyffier
Published 2015-01-01

From Clinical Trial Efficacy to Real-Life Effectiveness: Why Conventional Metrics do not Work

by Jean-Pierre Boissel, Frédéric Cogny, Nicholas Marko, François-Henri Boissel
Published 2019-07-01

Effect Model Law: An Approach for the Implementation of Personalized Medicine

by François-Henri Boissel, Draltan Marin, Riad Kahoul, Jean-Pierre Boissel
Published 2013-08-01

Treatment of high blood pressure and gain in event-free life expectancy

by Behrouz Kassaï, Jean-Pierre Boissel, Michel Cucherat, Florent Boutitie, François Gueyffier
Published 2005-07-01

The global risk approach should be better applied in French hypertensive patients: a comparison between simulation and observation studies.

by Ivanny Marchant, Patrice Nony, Michel Cucherat, Jean-Pierre Boissel, S Randall Thomas, Theodora Bejan-Angoulvant, Alexandra Laugerotte, Riad Kahoul, François Gueyffier
Published 2011-03-01

Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

by Rémy Boussageon, Irène Supper, Theodora Bejan-Angoulvant, Nadir Kellou, Michel Cucherat, Jean-Pierre Boissel, Behrouz Kassai, Alain Moreau, François Gueyffier, Catherine Cornu
Published 2012-01-01

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

by Flora T. Musuamba, Roberta Bursi, Efthymios Manolis, Kristin Karlsson, Alexander Kulesza, Eulalie Courcelles, Jean‐Pierre Boissel, Raphaëlle Lesage, Cécile Crozatier, Emmanuelle M. Voisin, Cécile F. Rousseau, Thierry Marchal, Rossana Alessandrello, Liesbet Geris
Published 2020-04-01

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

by Flora T. Musuamba, Ine Skottheim Rusten, Raphaëlle Lesage, Giulia Russo, Roberta Bursi, Luca Emili, Gaby Wangorsch, Efthymios Manolis, Kristin E. Karlsson, Alexander Kulesza, Eulalie Courcelles, Jean‐Pierre Boissel, Cécile F. Rousseau, Emmanuelle M. Voisin, Rossana Alessandrello, Nuno Curado, Enrico Dall’ara, Blanca Rodriguez, Francesco Pappalardo, Liesbet Geris
Published 2021-08-01