Developmental Defects in Trisomy 21 and Mouse Models

by Jean Maurice Delabar, Revital Aflalo-Rattenbac, Nicole Créau
Published 2006-01-01

One-carbon cycle alterations induced by Dyrk1a dosage

by Jean-Maurice Delabar, Alizée Latour, Christophe Noll, Marjorie Renon, Sacha Salameh, Jean-Louis Paul, Mariona Arbones, Jamileh Movassat, Nathalie Janel
Published 2014-01-01

Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia

by Alizée Latour, Sacha Salameh, Christel Carbonne, Fabrice Daubigney, Jean-Louis Paul, Micheline Kergoat, Valérie Autier, Jean-Maurice Delabar, Bart De Geest, Nathalie Janel
Published 2015-03-01

Proteomic shifts in embryonic stem cells with gene dose modifications suggest the presence of balancer proteins in protein regulatory networks.

by Lei Mao, Claus Zabel, Marion Herrmann, Tobias Nolden, Florian Mertes, Laetitia Magnol, Caroline Chabert, Daniela Hartl, Yann Herault, Jean Maurice Delabar, Thomas Manke, Heinz Himmelbauer, Joachim Klose
Published 2007-11-01

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

by Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar
Published 2014-09-01

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

by benoit esouchet, Fayçal eGuedj, zsuzsa ePenke-verdier, fabrice eDaubigney, Arnaud eDuchon, Yann eHerault, jean-charles eBizot, nathalie ejanel, nicole eCreau, Benoit eDelatour, Jean Maurice Delabar
Published 2015-10-01

Extensive natural variation for cellular hydrogen peroxide release is genetically controlled.

by Homa Attar, Karen Bedard, Eugenia Migliavacca, Maryline Gagnebin, Yann Dupré, Patrick Descombes, Christelle Borel, Samuel Deutsch, Holger Prokisch, Thomas Meitinger, Divya Mehta, Erich Wichmann, Jean Maurice Delabar, Emmanouil T Dermitzakis, Karl-Heinz Krause, Stylianos E Antonarakis
Published 2012-01-01

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase.

by Christophe Noll, Chris Planque, Clémentine Ripoll, Fayçal Guedj, Anna Diez, Véronique Ducros, Nicole Belin, Arnaud Duchon, Jean-Louis Paul, Anne Badel, Bénédicte de Freminville, Yann Grattau, Henri Bléhaut, Yann Herault, Nathalie Janel, Jean-Maurice Delabar
Published 2009-10-01

Molecular signatures of cardiac defects in Down syndrome lymphoblastoid cell lines suggest altered ciliome and Hedgehog pathways.

by Clémentine Ripoll, Isabelle Rivals, Emilie Ait Yahya-Graison, Luce Dauphinot, Evelyne Paly, Clothilde Mircher, Aimé Ravel, Yann Grattau, Henri Bléhaut, André Mégarbane, Guy Dembour, Bénédicte de Fréminville, Renaud Touraine, Nicole Créau, Marie Claude Potier, Jean Maurice Delabar
Published 2012-01-01