Mycobacterium tuberculosis DevR/DosR Dormancy Regulator Activation Mechanism: Dispensability of Phosphorylation, Cooperativity and Essentiality of α10 Helix.

by Saurabh Sharma, Jaya Sivaswami Tyagi
Published 2016-01-01

Determinants outside the DevR C-terminal domain are essential for cooperativity and robust activation of dormancy genes in Mycobacterium tuberculosis.

by Uma Shankar Gautam, Santosh Chauhan, Jaya Sivaswami Tyagi
Published 2011-01-01

Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C.

by Neetu Kumra Taneja, Sakshi Dhingra, Aditya Mittal, Mohit Naresh, Jaya Sivaswami Tyagi
Published 2010-01-01

Importance of the α10 helix for DevR activation: A road map for screening inhibitors against DevR-mediated dormancy of Mycobacterium tuberculosis

by Atul Vashist, D Prithvi Raj, Umesh Datta Gupta, Rajiv Bhat, Jaya Sivaswami Tyagi
Published 2016-01-01

Direct detection of Mycobacterium tuberculosis rifampin resistance in bio-safe stained sputum smears.

by Surabhi Lavania, Divya Anthwal, Manpreet Bhalla, Nagendra Singh, Sagarika Haldar, Jaya Sivaswami Tyagi
Published 2017-01-01

Multiple transcription factors co-regulate the Mycobacterium tuberculosis adaptation response to vitamin C

by Malobi Nandi, Kriti Sikri, Neha Chaudhary, Shekhar Chintamani Mande, Ravi Datta Sharma, Jaya Sivaswami Tyagi
Published 2019-11-01

Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis

by Shyamasree De Majumdar, Kriti Sikri, Payel Ghosh, Neetika Jaisinghani, Malobi Nandi, Sheetal Gandotra, Shekhar Mande, Jaya Sivaswami Tyagi
Published 2019-02-01

G-Quadruplex-Forming DNA Aptamers Inhibit the DNA-Binding Function of HupB and Mycobacterium tuberculosis Entry into Host Cells

by Priya Kalra, Subodh Kumar Mishra, Surinder Kaur, Amit Kumar, Hanumanthappa Krishna Prasad, Tarun Kumar Sharma, Jaya Sivaswami Tyagi
Published 2018-12-01

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

by Subodh Kumar Mishra, Uma Shankar, Neha Jain, Kriti Sikri, Jaya Sivaswami Tyagi, Tarun Kumar Sharma, Jean-Louis Mergny, Amit Kumar
Published 2019-06-01

Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs

by Kriti Sikri, Priyanka Duggal, Chanchal Kumar, Sakshi Dhingra Batra, Atul Vashist, Ashima Bhaskar, Kritika Tripathi, Tavpritesh Sethi, Amit Singh, Jaya Sivaswami Tyagi
Published 2018-05-01

Appropriate DevR (DosR)-mediated signaling determines transcriptional response, hypoxic viability and virulence of Mycobacterium tuberculosis.

by Shyamasree De Majumdar, Atul Vashist, Sakshi Dhingra, Rajesh Gupta, Alka Singh, Vijay K Challu, V D Ramanathan, Prahlad Kumar, Jaya Sivaswami Tyagi
Published 2012-01-01

Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis.

by Shyamasree De Majumdar, Deepak Sharma, Atul Vashist, Kohinoor Kaur, Neetu Kumra Taneja, Santosh Chauhan, Vijay K Challu, V D Ramanathan, V Balasangameshwara, Prahlad Kumar, Jaya Sivaswami Tyagi
Published 2010-02-01

Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children.

by Sagarika Haldar, Naveen Sankhyan, Neera Sharma, Anjali Bansal, Vitul Jain, V K Gupta, Monica Juneja, Devendra Mishra, Arti Kapil, Urvashi B Singh, Sheffali Gulati, Veena Kalra, Jaya Sivaswami Tyagi
Published 2012-01-01

Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistanc...

by Divya Anthwal, Surabhi Lavania, Rakesh Kumar Gupta, Ajoy Verma, Vithal Prasad Myneedu, Prem Prakash Sharma, Hitesh Verma, Viveksheel Malhotra, Ashawant Gupta, Nalini Kant Gupta, Rohit Sarin, Sagarika Haldar, Jaya Sivaswami Tyagi
Published 2019-01-01

Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis

by Abhijeet Dhiman, Chanchal Kumar, Subodh Kumar Mishra, Kriti Sikri, Ishara Datta, Pradeep Sharma, Tej P. Singh, Sagarika Haldar, Neera Sharma, Anjali Bansal, Yusra Ahmad, Amit Kumar, Tarun Kumar Sharma, Jaya Sivaswami Tyagi
Published 2019-12-01

Compatibility of a novel filter paper-based bio-safe sputum transport kit with line probe assay for diagnosing drug-resistant tuberculosis: a single-site evaluation study

by Divya Anthwal, Rakesh Kumar Gupta, Ritu Singhal, Manpreet Bhalla, Ajoy Kumar Verma, Khalid Umar Khayyam, Vithal Prasad Myneedu, Rohit Sarin, Ashawant Gupta, Nalini Kant Gupta, Manjula Singh, Jaya Sivaswami Tyagi, Sagarika Haldar
Published 2021-08-01

Utility of circulating cell-free Mycobacterium tuberculosis DNA for the improved diagnosis of abdominal tuberculosis.

by Pratibha Sharma, Divya Anthwal, Pooja Kumari, Rakesh Kumar Gupta, Surabhi Lavania, Neera Sharma, Lokesh Kumar Sharma, Deepak Rath, Pavan Kumar Soraganvi, Ashish Sharma, A K Gadpayle, R S Taneja, Jaya Sivaswami Tyagi, Sagarika Haldar
Published 2020-01-01