Incorporating Placebo Response in Quantitative Systems Pharmacology Models

by Evan B. Wang, Lei Shen, Michael Heathman, Jason R. Chan
Published 2019-06-01

A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

by Saroja Ramanujan, Jason R. Chan, Christina M. Friedrich, Craig J. Thalhauser
Published 2019-06-01

The Apoe-/- Mouse PhysioLab® Platform: A Validated Physiologically-based Mathematical Model of Atherosclerotic Plaque Progression in the Apoe-/- Mouse

by Jason R Chan, Gregory Vuillaume, Caitlin Bever, Stefan Lebrun, Michael Lietz, Yvonne Steffen, Katrin Stolle, Karim Wahba, Xiao Wang, Shonna Moodie, Julia Hoeng, Manuel C Peitsch, Lyn M Powell
Published 2012-09-01

Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection

by Joo-Yun Byun, Yi T. Koh, Sun Young Jang, Jennifer W. Witcher, Jason R. Chan, Anna Pustilnik, Mark J. Daniels, Young Hoon Kim, Kwee Hyun Suh, Matthew D. Linnik, Young-Mi Lee
Published 2021-09-01

Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities

by Erica L. Bradshaw, Mary E. Spilker, Richard Zang, Loveleena Bansal, Handan He, Rhys D.O. Jones, Kha Le, Mark Penney, Edgar Schuck, Brian Topp, Alice Tsai, Christine Xu, Marjoleen J.M.A. Nijsen, Jason R. Chan
Published 2019-11-01