The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

by Ilze Radovica, Davids Fridmanis, Iveta Vaivade, Liene Nikitina-Zake, Janis Klovins
Published 2013-01-01

Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness

by Gustavs Latkovskis, Inga Urtane, Agnese Knipse, Raitis Peculis, Inese Cakstina, Janis Klovins, Andrejs Erglis
Published 2014-01-01

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

by Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Published 2018-08-01

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

by Laila Silamiķele, Ivars Silamiķelis, Monta Ustinova, Zane Kalniņa, Ilze Elbere, Ramona Petrovska, Ineta Kalniņa, Jānis Kloviņš
Published 2021-03-01

Thiopurine -methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population

by Polina Zalizko, Juris Stefanovics, Jelizaveta Sokolovska, Natalia Paramonova, Evija Klavina, Renars Erts, Vita Rovite, Janis Klovins, Aldis Pukitis
Published 2020-07-01

The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot Study

by Natalija Vedmedovska, Diana Bokucava, Anda Kivite-Urtane, Vita Rovite, Liene Zake-Nikitina, Janis Klovins, Violeta Fodina, Gilbert G. G. Donders
Published 2020-08-01

Functional Characteristics of Multipotent Mesenchymal Stromal Cells from Pituitary Adenomas

by Kaspars Megnis, Ilona Mandrika, Ramona Petrovska, Janis Stukens, Vita Rovite, Inga Balcere, Laima Sabine Jansone, Raitis Peculis, Valdis Pirags, Janis Klovins
Published 2016-01-01

Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

by Monta Ustinova, Raitis Peculis, Raimonds Rescenko, Vita Rovite, Linda Zaharenko, Ilze Elbere, Laila Silamikele, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Published 2021-01-01

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.

by Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Published 2018-01-01

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response.

by Monta Ustinova, Laura Ansone, Ivars Silamikelis, Vita Rovite, Ilze Elbere, Laila Silamikele, Ineta Kalnina, Davids Fridmanis, Jelizaveta Sokolovska, Ilze Konrade, Valdis Pirags, Janis Klovins
Published 2020-01-01

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.

by Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Published 2019-01-01

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients.

by Ilze Elbere, Ivars Silamikelis, Ilze Izabella Dindune, Ineta Kalnina, Monta Ustinova, Linda Zaharenko, Laila Silamikele, Vita Rovite, Dita Gudra, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Published 2020-01-01

Pituispheres Contain Genetic Variants Characteristic to Pituitary Adenoma Tumor Tissue

by Raitis Peculis, Ilona Mandrika, Ramona Petrovska, Rasma Dortane, Kaspars Megnis, Jurijs Nazarovs, Inga Balcere, Inga Balcere, Janis Stukens, Ilze Konrade, Valdis Pirags, Valdis Pirags, Janis Klovins, Vita Rovite
Published 2020-05-01

Case report: recurrent pituitary adenoma has increased load of somatic variants

by Raitis Peculis, Inga Balcere, Ilze Radovica-Spalvina, Ilze Konrade, Olivija Caune, Kaspars Megnis, Vita Rovite, Janis Stukens, Jurijs Nazarovs, Austra Breiksa, Aigars Kiecis, Ivars Silamikelis, Valdis Pirags, Janis Klovins
Published 2020-01-01

Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma

by Kaspars Megnis, Raitis Peculis, Vita Rovite, Pola Laksa, Helvijs Niedra, Inga Balcere, Olivija Caune, Austra Breiksa, Jurijs Nazarovs, Janis Stukens, Ilze Konrade, Ilze Konrade, Valdis Pirags, Valdis Pirags, Valdis Pirags, Janis Klovins
Published 2019-09-01

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

by Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Published 2018-12-01

A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe.

by Andrey V Khrunin, Denis V Khokhrin, Irina N Filippova, Tõnu Esko, Mari Nelis, Natalia A Bebyakova, Natalia L Bolotova, Janis Klovins, Liene Nikitina-Zake, Karola Rehnström, Samuli Ripatti, Stefan Schreiber, Andre Franke, Milan Macek, Veronika Krulišová, Jan Lubinski, Andres Metspalu, Svetlana A Limborska
Published 2013-01-01

Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue

by Rihards Saksis, Ivars Silamikelis, Pola Laksa, Kaspars Megnis, Raitis Peculis, Ilona Mandrika, Olesja Rogoza, Ramona Petrovska, Inga Balcere, Inga Balcere, Ilze Konrade, Ilze Konrade, Liva Steina, Janis Stukens, Austra Breiksa, Jurijs Nazarovs, Jelizaveta Sokolovska, Valdis Pirags, Valdis Pirags, Janis Klovins, Vita Rovite
Published 2021-02-01

First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

by Nikita Zrelovs, Monta Ustinova, Ivars Silamikelis, Liga Birzniece, Kaspars Megnis, Vita Rovite, Lauma Freimane, Laila Silamikele, Laura Ansone, Janis Pjalkovskis, Davids Fridmanis, Baiba Vilne, Marta Priedite, Anastasija Caica, Mikus Gavars, Dmitry Perminov, Dmitry Perminov, Jelena Storozenko, Jelena Storozenko, Oksana Savicka, Oksana Savicka, Elina Dimina, Uga Dumpis, Uga Dumpis, Janis Klovins
Published 2021-04-01

Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations

by Kristiina Tambets, Bayazit Yunusbayev, Georgi Hudjashov, Anne-Mai Ilumäe, Siiri Rootsi, Terhi Honkola, Outi Vesakoski, Quentin Atkinson, Pontus Skoglund, Alena Kushniarevich, Sergey Litvinov, Maere Reidla, Ene Metspalu, Lehti Saag, Timo Rantanen, Monika Karmin, Jüri Parik, Sergey I. Zhadanov, Marina Gubina, Larisa D. Damba, Marina Bermisheva, Tuuli Reisberg, Khadizhat Dibirova, Irina Evseeva, Mari Nelis, Janis Klovins, Andres Metspalu, Tõnu Esko, Oleg Balanovsky, Elena Balanovska, Elza K. Khusnutdinova, Ludmila P. Osipova, Mikhail Voevoda, Richard Villems, Toomas Kivisild, Mait Metspalu
Published 2018-09-01