Evolutionary models for formation of network motifs and modularity in the Saccharomyces transcription factor network.

by Jonathan J Ward, Janet M Thornton
Published 2007-10-01

Proteins: interaction at a distance

by Roman A. Laskowski, Janet M. Thornton
Published 2015-11-01

PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure.

by Marialuisa Pellegrini-Calace, Tim Maiwald, Janet M Thornton
Published 2009-07-01

A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases

by Lorena Magraner-Pardo, Roman A. Laskowski, Tirso Pons, Janet M. Thornton
Published 2021-07-01

An automated protocol for modelling peptide substrates to proteases

by Rodrigo Ochoa, Mikhail Magnitov, Roman A. Laskowski, Pilar Cossio, Janet M. Thornton
Published 2020-12-01

Characterising Complex Enzyme Reaction Data.

by Handan Melike Dönertaş, Sergio Martínez Cuesta, Syed Asad Rahman, Janet M Thornton
Published 2016-01-01

Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.

by Irene Papatheodorou, Matthias Ziehm, Daniela Wieser, Nazif Alic, Linda Partridge, Janet M Thornton
Published 2012-01-01

Functional conservation in genes and pathways linking ageing and immunity

by Daniel K. Fabian, Matías Fuentealba, Handan Melike Dönertaş, Linda Partridge, Janet M. Thornton
Published 2021-05-01

Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders

by Rodrigo Ochoa, Rodrigo Ochoa, Roman A. Laskowski, Janet M. Thornton, Pilar Cossio, Pilar Cossio
Published 2021-03-01

Using the drug-protein interactome to identify anti-ageing compounds for humans.

by Matías Fuentealba, Handan Melike Dönertaş, Rhianna Williams, Johnathan Labbadia, Janet M Thornton, Linda Partridge
Published 2019-01-01

Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure.

by John A Capra, Roman A Laskowski, Janet M Thornton, Mona Singh, Thomas A Funkhouser
Published 2009-12-01

A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data.

by Dobril K Ivanov, Gerrit Bostelmann, Benoit Lan-Leung, Julie Williams, Linda Partridge, Valentina Escott-Price, Janet M Thornton
Published 2020-01-01

Amino acid changes in disease-associated variants differ radically from variants observed in the 1000 genomes project dataset.

by Tjaart A P de Beer, Roman A Laskowski, Sarah L Parks, Botond Sipos, Nick Goldman, Janet M Thornton
Published 2013-01-01

Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.

by Nicholas Furnham, Ian Sillitoe, Gemma L Holliday, Alison L Cuff, Roman A Laskowski, Christine A Orengo, Janet M Thornton
Published 2012-01-01

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.

by Cathy Slack, Christian Werz, Daniela Wieser, Nazif Alic, Andrea Foley, Hugo Stocker, Dominic J Withers, Janet M Thornton, Ernst Hafen, Linda Partridge
Published 2010-03-01

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.

by Nidhi Tyagi, Edward J Farnell, Colin M Fitzsimmons, Stephanie Ryan, Edridah Tukahebwa, Rick M Maizels, David W Dunne, Janet M Thornton, Nicholas Furnham
Published 2015-10-01

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

by Ekin Bolukbasi, Mobina Khericha, Jennifer C. Regan, Dobril K. Ivanov, Jennifer Adcott, Miranda C. Dyson, Tobias Nespital, Janet M. Thornton, Nazif Alic, Linda Partridge
Published 2017-10-01

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

by Daniel E. Martin-Herranz, Erfan Aref-Eshghi, Marc Jan Bonder, Thomas M. Stubbs, Sanaa Choufani, Rosanna Weksberg, Oliver Stegle, Bekim Sadikovic, Wolf Reik, Janet M. Thornton
Published 2019-08-01

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

by Jennifer M A Tullet, Caroline Araiz, Matthew J Sanders, Catherine Au, Alexandre Benedetto, Irene Papatheodorou, Emily Clark, Kathrin Schmeisser, Daniel Jones, Eugene F Schuster, Janet M Thornton, David Gems
Published 2014-02-01

Data-driven identification of ageing-related diseases from electronic health records

by Valerie Kuan, Helen C. Fraser, Melanie Hingorani, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Dorothea Nitsch, Rohini Mathur, Constantinos A. Parisinos, R. Thomas Lumbers, Reecha Sofat, Ian C. K. Wong, Juan P. Casas, Janet M. Thornton, Harry Hemingway, Linda Partridge, Aroon D. Hingorani
Published 2021-02-01