Development of ST-246® for Treatment of Poxvirus Infections

by Dennis E. Hruby, Janet M. Leeds, Robert Jordan, Shanthakumar Tyavanagimatt
Published 2010-11-01

Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.

by Adams Amantana, Yali Chen, Shanthakumar R Tyavanagimatt, Kevin F Jones, Robert Jordan, Jarasvech Chinsangaram, Tove C Bolken, Janet M Leeds, Dennis E Hruby
Published 2013-01-01

Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model.

by Genmin Lu, Polly Pine, Janet M Leeds, Francis DeGuzman, Pratikhya Pratikhya, Joyce Lin, John Malinowski, Stanley J Hollenbach, John T Curnutte, Pamela B Conley
Published 2018-01-01

Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.

by Yali Chen, Adams Amantana, Shanthakumar R Tyavanagimatt, Daniela Zima, X Steven Yan, Gopi Kasi, Morgan Weeks, Melialani A Stone, William C Weimers, Peter Samuel, Ying Tan, Kevin F Jones, Daniel R Lee, Shirley S Kickner, Bradley M Saville, Martin Lauzon, Alan McIntyre, Kady M Honeychurch, Robert Jordan, Dennis E Hruby, Janet M Leeds
Published 2011-01-01