Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection

by Christine E. Peters, Jan E. Carette
Published 2021-01-01

A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB.

by Clarissa C Lee, Jan E Carette, Thijn R Brummelkamp, Hidde L Ploegh
Published 2013-01-01

Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens.

by Bhaven B Patel, Andres M Lebensohn, Ganesh V Pusapati, Jan E Carette, Julia Salzman, Rajat Rohatgi
Published 2019-01-01

Differential and convergent utilization of autophagy components by positive-strand RNA viruses.

by Emma Abernathy, Roberto Mateo, Karim Majzoub, Nick van Buuren, Sara W Bird, Jan E Carette, Karla Kirkegaard
Published 2019-01-01

A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity

by Andreas S. Puschnik, Caleb D. Marceau, Yaw Shin Ooi, Karim Majzoub, Natalie Rinis, Joseph N. Contessa, Jan E. Carette
Published 2017-12-01

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

by Jennifer H. Lumb, Qin Li, Lauren M. Popov, Siyuan Ding, Marie T. Keith, Bryan D. Merrill, Harry B. Greenberg, Jin Billy Li, Jan E. Carette
Published 2017-07-01

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

by Jimit Shah, Florian Rouaud, Diego Guerrera, Ekaterina Vasileva, Lauren M. Popov, William L. Kelley, Eric Rubinstein, Jan E. Carette, Manuel R. Amieva, Sandra Citi
Published 2018-11-01

Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus

by Jim Baggen, Hendrik Jan Thibaut, Daniel L. Hurdiss, Maryam Wahedi, Caleb D. Marceau, Arno L. W. van Vliet, Jan E. Carette, Frank J. M. van Kuppeveld
Published 2019-08-01

Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread

by Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar
Published 2020-06-01

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

by Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi
Published 2020-05-01

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

by Walter W. Chen, Kıvanç Birsoy, Maria M. Mihaylova, Harriet Snitkin, Iwona Stasinski, Burcu Yucel, Erol C. Bayraktar, Jan E. Carette, Clary B. Clish, Thijn R. Brummelkamp, David D. Sabatini, David M. Sabatini
Published 2014-04-01

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

by Esther Ndungo, Andrew S. Herbert, Matthijs Raaben, Gregor Obernosterer, Rohan Biswas, Emily Happy Miller, Ariel S. Wirchnianski, Jan E. Carette, Thijn R. Brummelkamp, Sean P. Whelan, John M. Dye, Kartik Chandran, W. Paul Duprex
Published 2016-03-01

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

by Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist
Published 2015-09-01

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

by Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F. Brulois, Linda L. Yasukawa, Xingnan Li, Calvin J. Kuo, David A. Solomon, Jan E. Carette, Harry B. Greenberg
Published 2018-04-01

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

by Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, Jin Wang, Jason W. Locasale, Everett Stone, Susan P.C. Cole, Jan E. Carette, Scott J. Dixon
Published 2019-02-01

Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

by Andres M Lebensohn, Ramin Dubey, Leif R Neitzel, Ofelia Tacchelly-Benites, Eungi Yang, Caleb D Marceau, Eric M Davis, Bhaven B Patel, Zahra Bahrami-Nejad, Kyle J Travaglini, Yashi Ahmed, Ethan Lee, Jan E Carette, Rajat Rohatgi
Published 2016-12-01

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

by Benjamin G Gowen, Bryan Chim, Caleb D Marceau, Trever T Greene, Patrick Burr, Jeanmarie R Gonzalez, Charles R Hesser, Peter A Dietzen, Teal Russell, Alexandre Iannello, Laurent Coscoy, Charles L Sentman, Jan E Carette, Stefan A Muljo, David H Raulet
Published 2015-11-01

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

by Derrick C. Wan, Stefanie L. Morgan, Andrew L. Spencley, Natasha Mariano, Erin Y. Chang, Gautam Shankar, Yunhai Luo, Ted H. Li, Dana Huh, Star K. Huynh, Jasmine M. Garcia, Cole M. Dovey, Jennifer Lumb, Ling Liu, Katharine V. Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L. Mascetti, Sharon J. Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A. Rando, Jan E. Carette, J. Fernando Bazan, Kevin C. Wang
Published 2018-12-01