Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice

by Hani Jouihan, Sarah Will, Silvia Guionaud, Michelle L. Boland, Stephanie Oldham, Peter Ravn, Anthony Celeste, James L. Trevaskis
Published 2017-11-01

Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight.

by Carrie McMahon, James L Trevaskis, Christoph Carter, Kevin Holsapple, Kirsten White, Moupali Das, Sean Collins, Hal Martin, Leigh Ann Burns-Naas
Published 2020-01-01

The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery

by Brandon Boland, Michael B. Mumphrey, Zheng Hao, Benji Gill, R. Leigh Townsend, Sangho Yu, Heike Münzberg, Christopher D. Morrison, James L. Trevaskis, Hans-Rudolf Berthoud
Published 2019-03-01

Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice

by Brandon B. Boland, Michael B. Mumphrey, Zheng Hao, R. Leigh Townsend, Benji Gill, Stephanie Oldham, Sarah Will, Christopher D. Morrison, Sangho Yu, Heike Münzberg, Christopher J. Rhodes, James L. Trevaskis, Hans-Rudolf Berthoud
Published 2019-07-01

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat).

by Briana Spolding, Timothy Connor, Carrie Wittmer, Lelia L F Abreu, Antony Kaspi, Mark Ziemann, Gunveen Kaur, Adrian Cooper, Shona Morrison, Scott Lee, Andrew Sinclair, Yann Gibert, James L Trevaskis, Jonathon D Roth, Assam El-Osta, Richard Standish, Ken Walder
Published 2014-01-01

Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids.

by James L Trevaskis, Christine M Mack, Chengzao Sun, Christopher J Soares, Lawrence J D'Souza, Odile E Levy, Diane Y Lewis, Carolyn M Jodka, Krystyna Tatarkiewicz, Bronislava Gedulin, Swati Gupta, Carrie Wittmer, Michael Hanley, Bruce Forood, David G Parkes, Soumitra S Ghosh
Published 2013-01-01

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

by Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang, Jacob Jelsing, Kristoffer T. G. Rigbolt
Published 2020-07-01