The diverse roles of cysteine proteases in parasites and their suitability as drug targets.

by James H McKerrow
Published 2018-08-01

Designing drugs for parasitic diseases of the developing world.

by James H McKerrow
Published 2005-08-01

Molecular and biochemical studies of the cercarial proteinase of Schistosoma mansoni

by James H. McKerrow
Published 1989-01-01

Update on drug development targeting parasite cysteine proteases.

by James H McKerrow
Published 2018-08-01

Schistosome serine protease inhibitors: parasite defense or homeostasis?

by Landys A. Lopez Quezada, James H McKerrow
Published 2011-06-01

The rule of five should not impede anti-parasitic drug development

by James H. McKerrow, Christopher A. Lipinski, Ph.D., LLC
Published 2017-08-01

Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis.

by Laura-Isobel McCall, Jair L Siqueira-Neto, James H McKerrow
Published 2016-05-01

Inhibición de la Cruzaína: estrategia molecular en la búsqueda de nuevos fármacos para el Mal de Chagas

by Jorge A. Huete-Pérez, Ricardo A. Huete, Iván Marín, James H. McKerrow
Published 2000-02-01

Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs.

by Maha-Hamadien Abdulla, Kee-Chong Lim, James H McKerrow, Conor R Caffrey
Published 2011-10-01

Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines.

by Shuyi Zhang, Charles C Kim, Sajeev Batra, James H McKerrow, P'ng Loke
Published 2010-03-01

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

by Susan T Mashiyama, Kyriacos Koupparis, Conor R Caffrey, James H McKerrow, Patricia C Babbitt
Published 2012-01-01

Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.

by Maha-Hamadien Abdulla, Kee-Chong Lim, Mohammed Sajid, James H McKerrow, Conor R Caffrey
Published 2007-01-01

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

by Anjan Debnath, Andrew T. Nelson, Angélica Silva-Olivares, Mineko Shibayama, Dionicio Siegel, James H. McKerrow
Published 2018-03-01

Heat Shock Protein 90 Inhibitors repurposed against Entamoeba histolytica

by Dea eShahinas, Anjan eDebnath, Christan eBenedict, James H McKerrow, Dylan R Pillai
Published 2015-04-01

The Trypanosoma cruzi protease cruzain mediates immune evasion.

by Patricia S Doyle, Yuan M Zhou, Ivy Hsieh, Doron C Greenbaum, James H McKerrow, Juan C Engel
Published 2011-09-01

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.

by Maha-Hamadien Abdulla, Theresa O'Brien, Zachary B Mackey, Mohamed Sajid, Dennis J Grab, James H McKerrow
Published 2008-09-01

Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

by Chiung-Kuang Chen, Siegfried S F Leung, Christophe Guilbert, Matthew P Jacobson, James H McKerrow, Larissa M Podust
Published 2010-04-01

Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms.

by Karina M Rebello, James H McKerrow, Ester M Mota, Anthony J O Donoghue, Ana Gisele C Neves-Ferreira
Published 2018-10-01

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit.

by Geraldine De Muylder, Kenny K H Ang, Steven Chen, Michelle R Arkin, Juan C Engel, James H McKerrow
Published 2011-07-01

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

by Yen Ting Chen, Linda S Brinen, Iain D Kerr, Elizabeth Hansell, Patricia S Doyle, James H McKerrow, William R Roush
Published 2010-09-01