Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK.

by Sandeep Chhabra, Nicholas Barlow, Olan Dolezal, Meghan K Hattarki, Janet Newman, Thomas S Peat, Bim Graham, James D Swarbrick
Published 2013-01-01

Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor.

by Sandeep Chhabra, Olan Dolezal, Brett M Collins, Janet Newman, Jamie S Simpson, Ian G Macreadie, Ross Fernley, Thomas S Peat, James D Swarbrick
Published 2012-01-01

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins.

by James D Swarbrick, Daniel J Shaw, Sandeep Chhabra, Rajesh Ghai, Eugene Valkov, Suzanne J Norwood, Matthew N J Seaman, Brett M Collins
Published 2011-01-01