Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

by Franziska Paech, Franziska Paech, Jamal Bouitbir, Jamal Bouitbir, Jamal Bouitbir, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl
Published 2017-06-01

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

by Noëmi Johanna Roos, Noëmi Johanna Roos, Noëmi Johanna Roos, Diell Aliu, Diell Aliu, Jamal Bouitbir, Jamal Bouitbir, Jamal Bouitbir, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl
Published 2020-06-01

Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

by Jamal Bouitbir, Jamal Bouitbir, Jamal Bouitbir, Miljenko Valentin Panajatovic, Miljenko Valentin Panajatovic, Theo Frechard, Theo Frechard, Noëmi Johanna Roos, Noëmi Johanna Roos, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl
Published 2020-07-01

Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression

by Miljenko Valentin Panajatovic, François Singh, Stephan Krähenbühl, Jamal Bouitbir
Published 2020-09-01

Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression

by Miljenko V. Panajatovic, Francois Singh, Stephan Krähenbühl, Jamal Bouitbir
Published 2021-05-01

Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis

by Deborah Rudin, Maurice Schmutz, Noëmi Johanna Roos, Jamal Bouitbir, Stephan Krähenbühl
Published 2020-07-01

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

by Cristina Gómez, Simon Stücheli, Denise V. Kratschmar, Jamal Bouitbir, Alex Odermatt
Published 2020-07-01

Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient

by Tim Bühler, Michael Medinger, Jamal Bouitbir, Stephan Krähenbühl, Anne Leuppi-Taegtmeyer
Published 2019-06-01

Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones

by Xun Zhou, Jamal Bouitbir, Matthias E. Liechti, Stephan Krähenbühl, Riccardo V. Mancuso
Published 2020-04-01

<i>Para</i>-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells

by Xun Zhou, Jamal Bouitbir, Matthias E. Liechti, Stephan Krähenbühl, Riccardo V. Mancuso
Published 2020-04-01

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice.

by Patrizia Haegler, David Grünig, Benjamin Berger, Luigi Terracciano, Stephan Krähenbühl, Jamal Bouitbir
Published 2017-01-01

Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04

by Karin Brecht, Carla Kirchhofer, Jamal Bouitbir, Francesca Trapani, Jennifer Keiser, Stephan Krähenbühl
Published 2019-10-01

Impaired exercise performance and skeletal muscle mitochondrial function in rats with secondary carnitine deficiency

by Jamal BOUITBIR, Patrizia HAEGLER, François SINGH, Lorenz JOERIN, Andrea FELSER, Urs DUTHALER, Stephan KRAEHENBUEHL
Published 2016-08-01

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts

by Xun Zhou, Dino Luethi, Gerda M. Sanvee, Jamal Bouitbir, Matthias E. Liechti, Stephan Krähenbühl
Published 2019-03-01

Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group St...

by Lea S Blaser, Urs Duthaler, Urs Duthaler, Jamal Bouitbir, Jamal Bouitbir, Anne B Leuppi-Taegtmeyer, Anne B Leuppi-Taegtmeyer, Evangelia Liakoni, Reto Dolf, Michael Mayr, Jürgen Drewe, Stephan Krähenbühl, Stephan Krähenbühl, Stephan Krähenbühl, Manuel Haschke
Published 2021-09-01

Left ventricular transmural gradient in mitochondrial respiration is associated with increased sub-endocardium nitric oxide and reactive oxygen species productions

by Michel KINDO, Michel KINDO, Sebastien GERELLI, Sebastien GERELLI, Jamal BOUITBIR, Jamal BOUITBIR, Tam HOANG MINH, Tam HOANG MINH, Anne-Laure CHARLES, Anne-Laure CHARLES, Jean-Philippe MAZZUCOTELLI, Joffrey ZOLL, Joffrey ZOLL, Francois PIQUARD, Francois PIQUARD, Bernard GENY, Bernard GENY
Published 2016-08-01

Age Modulates Fe3O4 Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young R...

by Yosra Baratli, Anne-Laure Charles, Valérie Wolff, Lotfi Ben Tahar, Leila Smiri, Jamal Bouitbir, Joffrey Zoll, Mohsen Sakly, Cyril Auger, Thomas Vogel, Hafedh Abdelmelek, Olfa Tebourbi, Bernard Geny
Published 2014-01-01

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

by Julien Pottecher, Julien Pottecher, Chris Adamopoulos, Chris Adamopoulos, Anne Lejay, Anne Lejay, Jamal Bouitbir, Anne-Laure Charles, Anne-Laure Charles, Alain Meyer, Alain Meyer, Mervyn Singer, Valerie Wolff, Valerie Wolff, Pierre Diemunsch, Pierre Diemunsch, Gilles Laverny, Daniel Metzger, Bernard Geny, Bernard Geny
Published 2018-05-01

Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age

by Judith Eschbach, Jérôme Sinniger, Jamal Bouitbir, Anissa Fergani, Anna-Isabel Schlagowski, Joffrey Zoll, Bernard Geny, Frédérique René, Yves Larmet, Vincent Marion, Robert H. Baloh, Matthew B. Harms, Michael E. Shy, Nadia Messadeq, Patrick Weydt, Jean-Philippe Loeffler, Albert C. Ludolph, Luc Dupuis
Published 2013-10-01