Antisense Gene Silencing: Therapy for Neurodegenerative Disorders?

by Troels T. Nielsen, Jørgen E. Nielsen
Published 2013-09-01

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B

by Yu Zhang, Benjamin Schmid, Troels T. Nielsen, Jørgen E. Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst, Kristine K. Freude
Published 2016-07-01

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B

by Yu Zhang, Benjamin Schmid, Troels T. Nielsen, Jørgen E. Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst, Kristine K. Freude
Published 2016-07-01

Allogenic hematopoietic stem cell transplantation in two siblings with adult metachromatic leukodystrophy and a systematic literature review

by Cecilie Videbæk, Jette Stokholm, Henrik Sengeløv, Lone U. Fjeldborg, Vibeke Andrée Larsen, Christian Krarup, Jørgen E. Nielsen, Sabine Grønborg
Published 2021-07-01

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

by Tong Li, Carlota Pires, Troels T. Nielsen, Gunhild Waldemar, Lena E. Hjermind, Jørgen E. Nielsen, Andras Dinnyes, Poul Hyttel, Kristine K. Freude
Published 2016-03-01

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1

by Tong Li, Carlota Pires, Troels T. Nielsen, Gunhild Waldemar, Lena E. Hjermind, Jørgen E. Nielsen, Andras Dinnyes, Bjørn Holst, Poul Hyttel, Kristine K. Freude
Published 2016-03-01

Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.

by Marie N N Hellem, Tua Vinther-Jensen, Lasse Anderberg, Esben Budtz-Jørgensen, Lena E Hjermind, Vibeke Andrée Larsen, Jørgen E Nielsen, Ian Law
Published 2021-01-01

The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.

by Silke Metzger, Carolin Walter, Olaf Riess, Raymund A C Roos, Jørgen E Nielsen, David Craufurd, REGISTRY Investigators of the European Huntington’s Disease Network, Huu Phuc Nguyen
Published 2013-01-01

Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.B11

by Susanne K. Hansen, Helena Borland, Lis F. Hasholt, Zeynep Tümer, Jørgen E. Nielsen, Mikkel A. Rasmussen, Troels T. Nielsen, Tina C. Stummann, Karina Fog, Poul Hyttel
Published 2016-05-01

Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line SCA3.A11

by Susanne K. Hansen, Helena Borland, Lis F. Hasholt, Zeynep Tümer, Jørgen E. Nielsen, Mikkel A. Rasmussen, Troels T. Nielsen, Tina C. Stummann, Karina Fog, Poul Hyttel
Published 2016-05-01

Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

by Carlota Pires, Benjamin Schmid, Carina Petræus, Anna Poon, Natakarn Nimsanor, Troels T. Nielsen, Gunhild Waldemar, Lena E. Hjermind, Jørgen E. Nielsen, Poul Hyttel, Kristine K. Freude
Published 2016-09-01

Reduced gluconeogenesis and lactate clearance in Huntington's disease

by Knud Josefsen, Signe M.B. Nielsen, André Campos, Thomas Seifert, Lis Hasholt, Jørgen E. Nielsen, Anne Nørremølle, Niels H. Skotte, Niels H. Secher, Bjørn Quistorff
Published 2010-12-01

Endophenotypical drift in Huntington’s disease: a 5-year follow-up study

by Marie N. N. Hellem, Rebecca K. Hendel, Tua Vinther-Jensen, Ida U. Larsen, Troels T. Nielsen, Lena E. Hjermind, Esben Budtz-Jørgensen, Asmus Vogel, Jørgen E. Nielsen
Published 2021-08-01

Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

by Blanca I. Aldana, Yu Zhang, Pia Jensen, Abinaya Chandrasekaran, Sofie K. Christensen, Troels T. Nielsen, Jørgen E. Nielsen, Poul Hyttel, Martin R. Larsen, Helle S. Waagepetersen, Kristine K. Freude
Published 2020-09-01

Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3

by Susanne K. Hansen, Tina C. Stummann, Helena Borland, Lis F. Hasholt, Zeynep Tümer, Jørgen E. Nielsen, Mikkel A. Rasmussen, Troels T. Nielsen, Justus C.A. Daechsel, Karina Fog, Poul Hyttel
Published 2016-09-01

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

by Anna Ochalek, Balázs Mihalik, Hasan X. Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E. Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyés
Published 2017-12-01

Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.

by Leire Valcárcel-Ocete, Gorka Alkorta-Aranburu, Mikel Iriondo, Asier Fullaondo, María García-Barcina, José Manuel Fernández-García, Elena Lezcano-García, José María Losada-Domingo, Javier Ruiz-Ojeda, Amaia Álvarez de Arcaya, José María Pérez-Ramos, Raymund A C Roos, Jørgen E Nielsen, Carsten Saft, REGISTRY investigators of the European Huntington's Disease Network, Ana M Zubiaga, Ana Aguirre
Published 2015-01-01

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

by Yu Zhang, Benjamin Schmid, Nanett K. Nikolaisen, Mikkel A. Rasmussen, Blanca I. Aldana, Mikkel Agger, Kirstine Calloe, Tina C. Stummann, Hjalte M. Larsen, Troels T. Nielsen, Jinrong Huang, Fengping Xu, Xin Liu, Lars Bolund, Morten Meyer, Lasse K. Bak, Helle S. Waagepetersen, Yonglun Luo, Jørgen E. Nielsen, Bjørn Holst, Christian Clausen, Poul Hyttel, Kristine K. Freude
Published 2017-03-01