Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

by Matthew J. Benskey, Rhyomi C. Sellnow, Ivette M. Sandoval, Ivette M. Sandoval, Caryl E. Sortwell, Caryl E. Sortwell, Jack W. Lipton, Jack W. Lipton, Fredric P. Manfredsson, Fredric P. Manfredsson
Published 2018-02-01

Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant.

by Brandee A Price, Ivette M Sandoval, Fung Chan, Ralph Nichols, Ramon Roman-Sanchez, Theodore G Wensel, John H Wilson
Published 2012-01-01

Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice.

by Ivette M Sandoval, Brandee A Price, Alecia K Gross, Fung Chan, Joshua D Sammons, John H Wilson, Theodore G Wensel
Published 2014-01-01

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

by Zhi-Hao Wang, Jie Xiang, Xia Liu, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Shengxi Wu, Jian-Zhi Wang, Keqiang Ye
Published 2019-07-01

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

by Rhyomi C. Sellnow, Jordan H. Newman, Nicole Chambers, Anthony R. West, Kathy Steece-Collier, Ivette M. Sandoval, Matthew J. Benskey, Christopher Bishop, Fredric P. Manfredsson
Published 2019-01-01

Impact of age and vector construct on striatal and nigral transgene expression

by Nicole K Polinski, Fredric P Manfredsson, Matthew J Benskey, D Luke Fischer, Christopher J Kemp, Kathy Steece-Collier, Ivette M Sandoval, Katrina L Paumier, Caryl E Sortwell
Published 2016-01-01

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

by Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower
Published 2018-04-01

Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

by Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Published 2019-11-01

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

by Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Published 2018-05-01

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

by Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Published 2021-01-01

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

by Katrina L. Paumier, Kelvin C. Luk, Fredric P. Manfredsson, Nicholas M. Kanaan, Jack W. Lipton, Timothy J. Collier, Kathy Steece-Collier, Christopher J. Kemp, Stephanie Celano, Emily Schulz, Ivette M. Sandoval, Sheila Fleming, Elliott Dirr, Nicole K. Polinski, John Q. Trojanowski, Virginia M. Lee, Caryl E. Sortwell
Published 2015-10-01