The Role of Zinc in Alzheimer's Disease

by Nicole T. Watt, Isobel J. Whitehouse, Nigel M. Hooper
Published 2011-01-01

Glypican-1 mediates both prion protein lipid raft association and disease isoform formation.

by David R Taylor, Isobel J Whitehouse, Nigel M Hooper
Published 2009-11-01

Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.

by Victoria Lewis, Isobel J Whitehouse, Herbert Baybutt, Jean C Manson, Steven J Collins, Nigel M Hooper
Published 2012-01-01

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

by Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper
Published 2016-01-01

Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage.

by Isobel J Whitehouse, J Scott Miners, Elizabeth B C Glennon, Patrick G Kehoe, Seth Love, Katherine A B Kellett, Nigel M Hooper
Published 2013-01-01

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging.

by Elizabeth B C Glennon, Isobel J Whitehouse, J Scott Miners, Patrick G Kehoe, Seth Love, Katherine A B Kellett, Nigel M Hooper
Published 2013-01-01