Druggable Transient Pockets in Protein Kinases

by Koji Umezawa, Isao Kii
Published 2021-01-01

Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells

by Naoki Ito, Isao Kii, Noriaki Shimizu, Hirotoshi Tanaka, Shin’ichi Takeda
Published 2017-08-01

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

by Samira Abu Jhaisha, Esti W. Widowati, Isao Kii, Rie Sonamoto, Stefan Knapp, Chrisovalantis Papadopoulos, Walter Becker
Published 2017-07-01

Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing.

by Takashi Nishiyama, Isao Kii, Takeshi G Kashima, Yoshinao Kikuchi, Atsushi Ohazama, Masashi Shimazaki, Masashi Fukayama, Akira Kudo
Published 2011-01-01

Remodeling of actin cytoskeleton in mouse periosteal cells under mechanical loading induces periosteal cell proliferation during bone formation.

by Daisuke Sakai, Isao Kii, Kazuki Nakagawa, Hiroko N Matsumoto, Masateru Takahashi, Suguru Yoshida, Takamitsu Hosoya, Kazuo Takakuda, Akira Kudo
Published 2011-01-01

Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells.

by Hideyuki Tanabe, Issei Takayama, Takashi Nishiyama, Masashi Shimazaki, Isao Kii, Minqi Li, Norio Amizuka, Ken-ichi Katsube, Akira Kudo
Published 2010-01-01

Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

by Hitomi Komura, Shota Kakio, Tomoya Sasahara, Yoshie Arai, Naomi Takino, Michio Sato, Kaori Satomura, Takayuki Ohnishi, Yo-ichi Nabeshima, Shin-ichi Muramatsu, Isao Kii, Minako Hoshi
Published 2019-03-01

Selective inhibition of the kinase DYRK1A by targeting its folding process

by Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara
Published 2016-04-01