Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis

by Jonathan Martinez-Fabregas, Elizabeth Pohler, Ignacio Moraga
Published 2021-06-01

Mapping Determinants of Cytokine Signaling via Protein Engineering

by Claire Gorby, Jonathan Martinez-Fabregas, Stephan Wilmes, Ignacio Moraga
Published 2018-09-01

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22.

by Yu Chen, Maud Vandereyken, Ian P Newton, Ignacio Moraga, Inke S Näthke, Mahima Swamy
Published 2019-11-01

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

by Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia
Published 2017-05-01

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

by Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Published 2019-11-01

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

by David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K. Christopher Garcia, Thomas D. Müller, Jacob Piehler
Published 2017-07-01

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

by Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga
Published 2021-04-01