Adjuvant activity of Mycobacteria-derived mycolic acids

by Mio Kubota, Ei'ichi Iizasa, Yasushi Chuuma, Hideyasu Kiyohara, Hiromitsu Hara, Hiroki Yoshida
Published 2020-05-01

Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.

by Honglian Tong, Yasunobu Miyake, Fumika Mi-Ichi, Yoichiro Iwakura, Hiromitsu Hara, Hiroki Yoshida
Published 2018-01-01

The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions.

by Tomokazu Tanaka, Yoshihiko Kitajima, Shuusuke Miyake, Kazuyoshi Yanagihara, Hiromitsu Hara, Aki Nishijima-Matsunobu, Koichi Baba, Masaaki Shida, Kota Wakiyama, Jun Nakamura, Hirokazu Noshiro
Published 2015-01-01

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

by Ei’ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, Masahiko Sugita, Goro Matsuzaki, Sho Yamasaki, Hiroki Yoshida, Hiromitsu Hara
Published 2021-04-01

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

by Masayuki Hayashi, Taiki Aoshi, Yasunari Haseda, Kouji Kobiyama, Edward Wijaya, Noriyuki Nakatsu, Yoshinobu Igarashi, Daron M. Standley, Hiroshi Yamada, Yoshikazu Honda-Okubo, Hiromitsu Hara, Takashi Saito, Toshiyuki Takai, Cevayir Coban, Nikolai Petrovsky, Ken J. Ishii
Published 2017-02-01

Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon.

by Seong Gyu Jeon, Hisako Kayama, Yoshiyasu Ueda, Takuya Takahashi, Takashi Asahara, Hirokazu Tsuji, Noriko M Tsuji, Hiroshi Kiyono, Ji Su Ma, Takashi Kusu, Ryu Okumura, Hiromitsu Hara, Hiroki Yoshida, Masahiro Yamamoto, Koji Nomoto, Kiyoshi Takeda
Published 2012-01-01