Impairment of the Hypothalamus–Pituitary–Thyroid Axis Caused by Naturally Occurring <i>GATA2</i> Mutations In Vitro

by Yuki Sakai, Kenji Ohba, Shigekazu Sasaki, Akio Matsushita, Hiroko Misawa Nakamura, Go Kuroda, Daisuke Tsuriya, Miho Yamashita, Takafumi Suda
Published 2021-09-01

Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production.

by Naoko Hirahara, Hiroko Misawa Nakamura, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Go Kuroda, Yuki Sakai, Shinsuke Shinkai, Hiroshi Haeno, Takuhiro Nishio, Shuichi Yoshida, Yutaka Oki, Takafumi Suda
Published 2020-01-01

Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph.

by Hideyuki Matsunaga, Shigekazu Sasaki, Shingo Suzuki, Akio Matsushita, Hirotoshi Nakamura, Hiroko Misawa Nakamura, Naoko Hirahara, Go Kuroda, Hiroyuki Iwaki, Kenji Ohba, Hiroshi Morita, Yutaka Oki, Takafumi Suda
Published 2015-01-01

G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor β2 in the rat hypothalamic paraventricular nucleus.

by Go Kuroda, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Yuki Sakai, Shinsuke Shinkai, Hiroko Misawa Nakamura, Satoru Yamagishi, Kohji Sato, Naoko Hirahara, Yutaka Oki, Masahiko Ito, Tetsuro Suzuki, Takafumi Suda
Published 2020-01-01