Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt

by Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Published 2017-10-01

Heat Shock Protein 70 Negatively Regulates TGF-β-Stimulated VEGF Synthesis via p38 MAP Kinase in Osteoblasts

by Go Sakai, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Published 2017-11-01

Down-Regulation by Resveratrol of Basic Fibroblast Growth Factor-Stimulated Osteoprotegerin Synthesis through Suppression of Akt in Osteoblasts

by Gen Kuroyanagi, Takanobu Otsuka, Naohiro Yamamoto, Rie Matsushima-Nishiwaki, Akira Nakakami, Jun Mizutani, Osamu Kozawa, Haruhiko Tokuda
Published 2014-10-01

HSP70 Inhibitor Suppresses IGF-I-Stimulated Migration of Osteoblasts through p44/p42 MAP Kinase

by Tetsu Kawabata, Haruhiko Tokuda, Go Sakai, Kazuhiko Fujita, Rie Matsushima-Nishiwaki, Gen Kuroyanagi, Takanobu Otsuka, Osamu Kozawa
Published 2018-11-01

Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways

by Tomoyuki Hioki, Haruhiko Tokuda, Gen Kuroyanagi, Woo Kim, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa
Published 2021-09-01

Postprandial Hyperglycemia Is Associated With White Matter Hyperintensity and Brain Atrophy in Older Patients With Type 2 Diabetes Mellitus

by Noriko Ogama, Noriko Ogama, Noriko Ogama, Takashi Sakurai, Takashi Sakurai, Shuji Kawashima, Shuji Kawashima, Takahisa Tanikawa, Haruhiko Tokuda, Haruhiko Tokuda, Shosuke Satake, Hisayuki Miura, Atsuya Shimizu, Manabu Kokubo, Shumpei Niida, Kenji Toba, Hiroyuki Umegaki, Masafumi Kuzuya, Masafumi Kuzuya
Published 2018-09-01

HSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts

by Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Published 2021-01-01

(-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts: Suppression of SAPK/JNK

by Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa
Published 2008-01-01

HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts.

by Kazuhiko Fujita, Haruhiko Tokuda, Gen Kuroyanagi, Naohiro Yamamoto, Shingo Kainuma, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka
Published 2017-01-01

Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase.

by Masanori Tsujimoto, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Yuko Kito, Yukiko Enomoto, Hiroki Iida, Shinji Ogura, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Toru Iwama
Published 2016-01-01

Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK

by Kodai Uematsu, Yukiko Enomoto, Takashi Onuma, Masanori Tsujimoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Haruhiko Tokuda, Shinji Ogura, Hiroki Iida, Osamu Kozawa, Toru Iwama
Published 2018-09-01

The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled T...

by Taiki Sugimoto, Taiki Sugimoto, Atsushi Araki, Hiroki Fujita, Keiko Honda, Nobuya Inagaki, Takeshi Ishida, Junichi Kato, Minoru Kishi, Kazuki Kobayashi, Kunichi Kouyama, Hisashi Noma, Mitsuru Ohishi, Noriko Satoh-Asahara, Hiroyuki Shimada, Kazuhiro Sugimoto, Susumu Suzuki, Yasushi Takeya, Yoshiaki Tamura, Haruhiko Tokuda, Haruhiko Tokuda, Hiroyuki Umegaki, Hirotaka Watada, Yuichiro Yamada, Takashi Sakurai, Takashi Sakurai
Published 2021-07-01

Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients

by Haruhiko Tokuda, Gen Kuroyanagi, Masanori Tsujimoto, Rie Matsushima-Nishiwaki, Shigeru Akamatsu, Yukiko Enomoto, Hiroki Iida, Takanobu Otsuka, Shinji Ogura, Toru Iwama, Kumi Kojima, Osamu Kozawa
Published 2016-05-01

Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus

by Noriko Ogama, Takashi Sakurai, Shuji Kawashima, Takahisa Tanikawa, Haruhiko Tokuda, Shosuke Satake, Hisayuki Miura, Atsuya Shimizu, Manabu Kokubo, Shumpei Niida, Kenji Toba, Hiroyuki Umegaki, Masafumi Kuzuya
Published 2019-03-01

Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation.

by Daiki Nakashima, Takashi Onuma, Kumiko Tanabe, Yuko Kito, Kodai Uematsu, Daisuke Mizutani, Yukiko Enomoto, Masanori Tsujimoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Haruhiko Tokuda, Shinji Ogura, Toru Iwama, Osamu Kozawa, Hiroki Iida
Published 2020-01-01

Tramadol enhances PGF2α-stimulated osteoprotegerin synthesis in osteoblasts

by Woo Kim, Kumiko Tanabe, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Junko Tachi, Tomoyuki Hioki, Daiki Nakashima, Shinobu Yamaguchi, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Hiroki Iida
Published 2020-08-01

Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients.

by Haruhiko Tokuda, Gen Kuroyanagi, Masanori Tsujimoto, Yukiko Enomoto, Rie Matsushima-Nishiwaki, Takashi Onuma, Akiko Kojima, Tomoaki Doi, Kumiko Tanabe, Shigeru Akamatsu, Hiroki Iida, Shinji Ogura, Takanobu Otsuka, Toru Iwama, Takahisa Tanikawa, Kei Ishikawa, Kumi Kojima, Osamu Kozawa
Published 2015-01-01