The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History

by Harry P. De Koning
Published 2020-01-01

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

by Jane Claire Munday, Luca eSettimo, Luca eSettimo, Harry P de Koning
Published 2015-03-01

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance

by Anthonius A. Eze, John Igoli, Alexander I. Gray, Graham G. Skellern, Harry P. De Koning
Published 2019-04-01

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

by Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser
Published 2015-08-01

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

by Abdulsalam A.M. Alkhaldi, Jan Martinek, Brian Panicucci, Christophe Dardonville, Alena Zíková, Harry P. de Koning
Published 2016-04-01

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.

by Juan F Quintana, Juan Bueren-Calabuig, Fabio Zuccotto, Harry P de Koning, David Horn, Mark C Field
Published 2020-07-01

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.

by Anne J N Kazibwe, Barbara Nerima, Harry P de Koning, Pascal Mäser, Michael P Barrett, Enock Matovu
Published 2009-09-01

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

by Godwin U. Ebiloma, Nahandoo Ichoron, Weam Siheri, David G. Watson, John O. Igoli, Harry P. De Koning
Published 2020-11-01

The ever unfolding story of cAMP signalling in trypanosomatids: vive la difference!

by Daniel Nii Aryee Tagoe, Daniel Nii Aryee Tagoe, Daniel Nii Aryee Tagoe, Titilola D. Kalejaiye, Harry P. De Koning
Published 2015-09-01

Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.

by Juma A M Ali, Daniel N A Tagoe, Jane C Munday, Anne Donachie, Liam J Morrison, Harry P de Koning
Published 2013-01-01

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

by Charles O. Nnadi, Godwin U. Ebiloma, Jennifer A. Black, Ngozi J. Nwodo, Leandro Lemgruber, Thomas J. Schmidt, Harry P. de Koning
Published 2019-01-01

Design and Synthesis of a Series of Truncated Neplanocin Fleximers

by Sarah C. Zimmermann, Elizaveta O'Neill, Godwin U. Ebiloma, Lynsey J. M. Wallace, Harry P. De Koning, Katherine L. Seley-Radtke
Published 2014-12-01

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

by Anthonius A Eze, Matthew K Gould, Jane C Munday, Daniel N A Tagoe, Valters Stelmanis, Achim Schnaufer, Harry P De Koning
Published 2016-08-01

Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples

by Samya S. Alenezi, Manal J. Natto, John O. Igoli, Alexander I. Gray, James Fearnley, Hugo Fearnley, Harry P. de Koning, David G. Watson
Published 2020-12-01

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

by Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Published 2019-12-01

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora

by Marzuq A. Ungogo, Marzuq A. Ungogo, Godwin U. Ebiloma, Nahandoo Ichoron, John O. Igoli, Harry P. de Koning, Emmanuel O. Balogun, Emmanuel O. Balogun
Published 2020-12-01

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

by Fabrice E Graf, Philipp Ludin, Tanja Wenzler, Marcel Kaiser, Reto Brun, Patient Pati Pyana, Philippe Büscher, Harry P de Koning, David Horn, Pascal Mäser
Published 2013-01-01

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

by Khalid J.H. Alzahrani, Juma A.M. Ali, Anthonius A. Eze, Wan Limm Looi, Daniel N.A. Tagoe, Darren J. Creek, Michael P. Barrett, Harry P. de Koning
Published 2017-08-01

Two New Antiprotozoal Diterpenes From the Roots of Acacia nilotica

by John V. Anyam, Priscilla E. Daikwo, Marzuq A. Ungogo, Marzuq A. Ungogo, Nwakaego E. Nweze, Ngozichukwuka P. Igoli, Alexander I. Gray, Harry P. De Koning, John O. Igoli
Published 2021-04-01

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.

by Juan D Unciti-Broceta, José L Arias, José Maceira, Miguel Soriano, Matilde Ortiz-González, José Hernández-Quero, Manuel Muñóz-Torres, Harry P de Koning, Stefan Magez, José A Garcia-Salcedo
Published 2015-06-01