Editorial of Special Column “Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)”

by Hai-Bin Luo, Shilin Chen, Peiqing Liu
Published 2020-07-01

Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine.

by Jing Hou, Jie Xu, Ming Liu, Ruizhi Zhao, Hai-Bin Luo, Hengming Ke
Published 2011-03-01

Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

by Zhang-Hua Sun, Ying-Hong Cai, Cheng-Qi Fan, Gui-Hua Tang, Hai-Bin Luo, Sheng Yin
Published 2014-01-01

Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities

by Jinxuan Li, Jing-Yi Chen, Ya-Lin Deng, Qian Zhou, Yinuo Wu, Deyan Wu, Hai-Bin Luo
Published 2018-05-01

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

by Chen Zhang, Qian Zhou, Xu-Nian Wu, Ya-Dan Huang, Jie Zhou, Zengwei Lai, Yinuo Wu, Hai-Bin Luo
Published 2018-01-01

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

by Senling Feng, Huifang Zhou, Deyan Wu, Dechong Zheng, Biao Qu, Ruiming Liu, Chen Zhang, Zhe Li, Ying Xie, Hai-Bin Luo
Published 2020-02-01

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

by Xu-Nian Wu, Ya-Dan Huang, Jin-Xuan Li, Yan-Fa Yu, Zhou Qian, Chen Zhang, Yinuo Wu, Hai-Bin Luo
Published 2018-07-01

Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study

by Sen-Ling Feng, Hai-Bin Luo, Liang Cai, Jie Zhang, Dan Wang, Ying-Jiang Chen, Huan-Xing Zhan, Zhi-Hong Jiang, Ying Xie
Published 2020-03-01

Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulm...

by Yuncong Yang, Sirui Zhang, Qian Zhou, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang, Lei Guo, Hai-Bin Luo
Published 2020-12-01

Heightened Local Th17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year

by Ming Liu, Bingtai Lu, Huifeng Fan, Xuanjie Guo, Shuling Du, Diyuan Yang, Yiping Xu, Yue Li, Di Che, Yunfeng Liu, Xiaoqiong Gu, Tao Ding, Ping Wang, Hai-bin Luo, Gen Lu
Published 2021-01-01

Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

by Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M. Lew, Jun Cui, Rongli Fang, Hui Huang, Jincun Zhao, Xuechuan Hong, Yuxia Zhang, Fuling Zhou, Hai-Bin Luo
Published 2020-07-01