Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

by Margarita Bartish, Sonia V. del Rincón, Sonia V. del Rincón, Christopher E. Rudd, Christopher E. Rudd, H. Uri Saragovi, H. Uri Saragovi, H. Uri Saragovi
Published 2020-09-01

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.

by Wenyong Tong, Mario Maira, Martin Gagnon, H Uri Saragovi
Published 2015-01-01

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

by Arturo Papaluca, J. Richard Wagner, H. Uri Saragovi, Dindial Ramotar
Published 2018-05-01

Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.

by Fouad Brahimi, Eunhwa Ko, Andrey Malakhov, Kevin Burgess, H Uri Saragovi
Published 2014-01-01

Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

by Sylvia Josephy-Hernandez, Sean Jmaeff, Iulia Pirvulescu, Tahar Aboulkassim, H. Uri Saragovi
Published 2017-01-01

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.

by Pablo F Barcelona, Alba Galan, Hinyu Nedev, Yifan Jian, Marinko V Sarunic, H Uri Saragovi
Published 2018-01-01

BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hear...

by Stephanie Szobota, Pranav D Mathur, Sairey Siegel, KristenAnn Black, H Uri Saragovi, Alan C Foster
Published 2019-01-01

Raft-dependent endocytosis of autocrine motility factor/phosphoglucose isomerase: a potential drug delivery route for tumor cells.

by Liliana D Kojic, Sam M Wiseman, Fariba Ghaidi, Bharat Joshi, Hinyu Nedev, H Uri Saragovi, Ivan R Nabi
Published 2008-01-01

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

by Sylvia Josephy-Hernandez, Iulia Pirvulescu, Mario Maira, Tahar Aboulkassim, Tak Pan Wong, R Anne McKinney, H Uri Saragovi
Published 2019-01-01

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1

by Zeljka Korade Mirnics, Chaohua Yan, Carmel Portugal, Tae-Wan Kim, H. Uri Saragovi, Sangram S. Sisodia, Karoly Mirnics, Nina F. Schor
Published 2005-12-01

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

by Fouad Brahimi, Alba Galan, Sean Jmaeff, Pablo F. Barcelona, Nicolas De Jay, Kurt Dejgaard, Jason C. Young, Claudia L. Kleinman, David Y. Thomas, H. Uri Saragovi
Published 2020-09-01

Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells.

by Alba Galan, Pauline Dergham, Pedro Escoll, Antonio de-la-Hera, Philippe M D'Onofrio, Mark M Magharious, Paulo D Koeberle, José María Frade, H Uri Saragovi
Published 2014-01-01

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

by Fouad Brahimi, Mario Maira, Pablo F Barcelona, Alba Galan, Tahar Aboulkassim, Katrina Teske, Mary-Louise Rogers, Lisa Bertram, Jing Wang, Masoud Yousefi, Robert Rush, Marc Fabian, Neil Cashman, H Uri Saragovi
Published 2016-01-01