A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK)

by Yan Yan, Xin Gu, H. Eric Xu, Karsten Melcher
Published 2017-10-01

Structure and Physiological Regulation of AMPK

by Yan Yan, X. Edward Zhou, H. Eric Xu, Karsten Melcher
Published 2018-11-01

Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.

by Shiva Kumar, Augen Pioszak, Chenghai Zhang, Kunchithapadam Swaminathan, H Eric Xu
Published 2011-01-01

H2O2 inhibits ABA-signaling protein phosphatase HAB1.

by Madhuri Sridharamurthy, Amanda Kovach, Yang Zhao, Jian-Kang Zhu, H Eric Xu, Kunchithapadam Swaminathan, Karsten Melcher
Published 2014-01-01

Abscisic acid signaling: thermal stability shift assays as tool to analyze hormone perception and signal transduction.

by Fen-Fen Soon, Kelly M Suino-Powell, Jun Li, Eu-Leong Yong, H Eric Xu, Karsten Melcher
Published 2012-01-01

The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

by Nanda Kumar Sasi, Kanchan Tiwari, Fen-Fen Soon, Dorine Bonte, Tong Wang, Karsten Melcher, H Eric Xu, Michael Weinreich
Published 2014-01-01

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling.

by Parker W de Waal, Jingjing Shi, Erli You, Xiaoxi Wang, Karsten Melcher, Yi Jiang, H Eric Xu, Bradley M Dickson
Published 2020-04-01

Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach.

by Katie R Martin, Pooja Narang, Yong Xu, Audra L Kauffman, Joachim Petit, H Eric Xu, Nathalie Meurice, Jeffrey P MacKeigan
Published 2012-01-01

Structural basis of Fusarium myosin I inhibition by phenamacril.

by Yuxin Zhou, X Edward Zhou, Yuanping Gong, Yuanye Zhu, Xiaoman Cao, Joseph S Brunzelle, H Eric Xu, Mingguo Zhou, Karsten Melcher, Feng Zhang
Published 2020-03-01

The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation.

by M H Eileen Tan, X Edward Zhou, Fen-Fen Soon, Xiaodan Li, Jun Li, Eu-Leong Yong, Karsten Melcher, H Eric Xu
Published 2013-01-01

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

by Sangwon Byun, Sunmi Seok, Young-Chae Kim, Yang Zhang, Peter Yau, Naoki Iwamori, H. Eric Xu, Jian Ma, Byron Kemper, Jongsook Kim Kemper
Published 2020-02-01

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

by Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H. Eric Xu, Xin Xie, Yi Jiang
Published 2021-08-01

Modulation of β-catenin signaling by glucagon receptor activation.

by Jiyuan Ke, Chenghai Zhang, Kaleeckal G Harikumar, Cassandra R Zylstra-Diegel, Liren Wang, Laura E Mowry, Laurence J Miller, Bart O Williams, H Eric Xu
Published 2012-01-01

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

by Sangwon Byun, Dong-Hyun Kim, Daniel Ryerson, Young-Chae Kim, Hao Sun, Bo Kong, Peter Yau, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper
Published 2018-07-01

The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine

by Hong Li, Lihua Zhao, Rani Singh, J. Nina Ham, Doris O. Fadoju, Lora J.H. Bean, Yan Zhang, Yong Xu, H. Eric Xu, Michael J. Gambello
Published 2018-12-01

Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

by Schoen W Kruse, Kelly Suino-Powell, X Edward Zhou, Jennifer E Kretschman, Ross Reynolds, Clemens Vonrhein, Yong Xu, Liliang Wang, Sophia Y Tsai, Ming-Jer Tsai, H Eric Xu
Published 2008-09-01

Combining chemical and genetic approaches to increase drought resistance in plants

by Min-Jie Cao, Yu-Lu Zhang, Xue Liu, Huan Huang, X. Edward Zhou, Wen-Long Wang, Ai Zeng, Chun-Zhao Zhao, Tong Si, Jiamu Du, Wen-Wu Wu, Fu-Xing Wang, H. Eric Xu, Jian-Kang Zhu
Published 2017-10-01

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

by Youwen Zhuang, Heng Liu, X. Edward Zhou, Ravi Kumar Verma, Parker W. de Waal, Wonjo Jang, Ting-Hai Xu, Lei Wang, Xing Meng, Gongpu Zhao, Yanyong Kang, Karsten Melcher, Hao Fan, Nevin A. Lambert, H. Eric Xu, Cheng Zhang
Published 2020-02-01

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

by Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dan-Dan Shen, Yan Zhang, Tian Xia, Raymond C Stevens, H Eric Xu, Dehua Yang, Lihua Zhao, Ming-Wei Wang
Published 2021-07-01

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

by Zhaotong Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou, Xinyu Zou, Chenyu Ye, Antao Dai, Qing Liu, Wei Huang, Xianqiang Sun, Xi Wang, Peiyu Xu, Lihua Zhao, Tian Xia, Wenge Zhong, Dehua Yang, H. Eric Xu, Yan Zhang, Ming-Wei Wang
Published 2021-06-01