TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells

by Laura F. Corns, Jing-Yi Jeng, Guy P. Richardson, Corné J. Kros, Walter Marcotti
Published 2017-10-01

Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine’s Potential

by Paromita Majumder, Jonathan E. Gale, Jonathan E. Gale, Paulette A. Moore, Guy P. Richardson
Published 2017-04-01

Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells

by Molly O’Reilly, Luke Young, Nerissa K. Kirkwood, Guy P. Richardson, Corné J. Kros, Anthony L. Moore
Published 2019-09-01

Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113

by Richard J. Goodyear, Mary Ann Cheatham, Mary Ann Cheatham, Souvik Naskar, Yingjie Zhou, Richard T. Osgood, Jing Zheng, Jing Zheng, Guy P. Richardson
Published 2019-06-01

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.

by Kumar N Alagramam, Richard J Goodyear, Ruishuang Geng, David N Furness, Alexander F J van Aken, Walter Marcotti, Corné J Kros, Guy P Richardson
Published 2011-04-01

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

by Nerissa K. Kirkwood, Molly O'Reilly, Marco Derudas, Emma J. Kenyon, Rosemary Huckvale, Sietse M. van Netten, Simon E. Ward, Guy P. Richardson, Corné J. Kros
Published 2017-09-01

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

by Kathryn Quick, Jing Zhao, Niels Eijkelkamp, John E. Linley, Francois Rugiero, James J. Cox, Ramin Raouf, Martine Gringhuis, Jane E. Sexton, Joel Abramowitz, Ruth Taylor, Andy Forge, Jonathan Ashmore, Nerissa Kirkwood, Corné J. Kros, Guy P. Richardson, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer, John N. Wood
Published 2012-01-01

Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

by Emma J. Kenyon, Nerissa K. Kirkwood, Siân R. Kitcher, Richard J. Goodyear, Marco Derudas, Daire M. Cantillon, Sarah Baxendale, Antonio de la Vega de León, Virginia N. Mahieu, Richard T. Osgood, Charlotte Donald Wilson, James C. Bull, Simon J. Waddell, Tanya T. Whitfield, Simon E. Ward, Corné J. Kros, Guy P. Richardson
Published 2021-04-01

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

by Rolen M. Quadros, Hiromi Miura, Donald W. Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P. Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M. Buckley, Parthasarathy Seshacharyulu, Surinder K. Batra, Mark A. Behlke, Sarah A. Zeiner, Ashley M. Jacobi, Yayoi Izu, Wallace B. Thoreson, Lisa D. Urness, Suzanne L. Mansour, Masato Ohtsuka, Channabasavaiah B. Gurumurthy
Published 2017-05-01