The role of mitochondrial DNA mutations in mammalian aging.

by Gregory C Kujoth, Patrick C Bradshaw, Suraiya Haroon, Tomas A Prolla
Published 2007-02-01

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

by Shinichi Someya, Gregory C Kujoth, Mi-Jung Kim, Timothy A Hacker, Marc Vermulst, Richard Weindruch, Tomas A Prolla
Published 2017-01-01

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

by Gregory C. Kujoth, Thomas D. Sullivan, Richard Merkhofer, Taek-Jin Lee, Huafeng Wang, Tristan Brandhorst, Marcel Wuthrich, Bruce S. Klein, Joseph Heitman
Published 2018-04-01

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

by Anna-Maria Joseph, Peter J Adhihetty, Nicholas R Wawrzyniak, Stephanie E Wohlgemuth, Anna Picca, Gregory C Kujoth, Tomas A Prolla, Christiaan Leeuwenburgh
Published 2013-01-01

Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition

by Ryota Kuroki, Yui Murata, Satoshi Fuke, Yutaka Nakachi, Jun Nakashima, Gregory C. Kujoth, Tomas A. Prolla, Miki Bundo, Miki Bundo, Tadafumi Kato, Kazuya Iwamoto
Published 2020-09-01

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.

by Asimina Hiona, Alberto Sanz, Gregory C Kujoth, Reinald Pamplona, Arnold Y Seo, Tim Hofer, Shinichi Someya, Takuya Miyakawa, Chie Nakayama, Alejandro K Samhan-Arias, Stephane Servais, Jamie L Barger, Manuel Portero-Otín, Masaru Tanokura, Tomas A Prolla, Christiaan Leeuwenburgh
Published 2010-07-01

Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity.

by Lucas Dos Santos Dias, Hannah E Dobson, Brock Kingstad Bakke, Gregory C Kujoth, Junfeng Huang, Elaine M Kohn, Cleison Ledesma Taira, Huafeng Wang, Nitin T Supekar, J Scott Fites, Daisy Gates, Christina L Gomez, Charles A Specht, Stuart M Levitz, Parastoo Azadi, Lingjun Li, Marulasiddappa Suresh, Bruce S Klein, Marcel Wüthrich
Published 2021-03-01