Modulating the expression of disease genes with RNA-based therapy.

by Matthew Wood, Haifang Yin, Graham McClorey
Published 2007-06-01

Splice-Switching Therapy for Spinal Muscular Atrophy

by Katharina E. Meijboom, Matthew J.A. Wood, Graham McClorey
Published 2017-06-01

Small RNA-Mediated Epigenetic Myostatin Silencing

by Thomas C Roberts, Samir EL Andaloussi, Kevin V Morris, Graham McClorey, Matthew JA Wood
Published 2012-01-01

Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of D...

by Alberto Malerba, Jagjeet K Kang, Graham McClorey, Amer F Saleh, Linda Popplewell, Michael J Gait, Matthew JA Wood, George Dickson
Published 2012-01-01

Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy

by Thomas C Roberts, K Emelie M Blomberg, Graham McClorey, Samir EL Andaloussi, Caroline Godfrey, Corinne Betts, Thibault Coursindel, Michael J Gait, CI Edvard Smith, Matthew JA Wood
Published 2012-01-01

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy.

by Alison M Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A Betts, Caroline Godfrey, Liz O'Donovan, Thibault Coursindel, Mike J Gait, Matthew J Wood, Guy A MacGowan, Volker W Straub
Published 2018-01-01

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides

by Suzan M Hammond, Graham McClorey, Joel Z Nordin, Caroline Godfrey, Sofia Stenler, Kim A Lennox, CI Edvard Smith, Ashley M Jacobi, Miguel A Varela, Yi Lee, Mark A Behlke, Matthew J A Wood, Samir E L Andaloussi
Published 2014-01-01

Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

by Tirsa L.E. vanWestering, Yulia Lomonosova, Anna M.L. Coenen‐Stass, Corinne A. Betts, Amarjit Bhomra, Margriet Hulsker, Lucy E. Clark, Graham McClorey, Annemieke Aartsma‐Rus, Maaike vanPutten, Matthew J.A. Wood, Thomas C. Roberts
Published 2020-04-01