ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids

by Anastasia Tsakmaki, Patricia Fonseca Pedro, Polychronis Pavlidis, Bu’Hussain Hayee, Gavin A. Bewick
Published 2020-04-01

Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

by Luis Fernando Delgadillo-Silva, Anastasia Tsakmaki, Nadeem Akhtar, Zara J. Franklin, Judith Konantz, Gavin A. Bewick, Nikolay Ninov
Published 2019-01-01

Histologic assessment of the intestinal wall following duodenal mucosal resurfacing (DMR): a new procedure for the treatment of insulin-resistant metabolic disease

by Eduardo G. H. de Moura, Alberto M. Ponte-Neto, Anastasia Tsakmaki, Vera Demarchi Aiello, Gavin A. Bewick, Vitor O. Brunaldi
Published 2019-05-01

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism.

by Jason A West, Anastasia Tsakmaki, Soumitra S Ghosh, David G Parkes, Rikke V Grønlund, Philip J Pedersen, David Maggs, Harith Rajagopalan, Gavin A Bewick
Published 2021-01-01

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

by Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov
Published 2018-04-01

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

by Lucy Brooks, Alexander Viardot, Anastasia Tsakmaki, Emilie Stolarczyk, Jane K. Howard, Patrice D. Cani, Amandine Everard, Michelle L. Sleeth, Arianna Psichas, Jelena Anastasovskaj, Jimmy D. Bell, Kim Bell-Anderson, Charles R. Mackay, Mohammad A. Ghatei, Stephen R. Bloom, Gary Frost, Gavin A. Bewick
Published 2017-01-01

Enteroendocrine Progenitor Cell–Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent MannerSummary

by Ajeet P. Singh, Yu-Han Hung, Michael T. Shanahan, Matt Kanke, Alessandro Bonfini, Michael K. Dame, Mandy Biraud, Bailey C.E. Peck, Oyebola O. Oyesola, John M. Freund, Rebecca L. Cubitt, Ennessa G. Curry, Liara M. Gonzalez, Gavin A. Bewick, Elia D. Tait-Wojno, Natasza A. Kurpios, Shengli Ding, Jason R. Spence, Christopher M. Dekaney, Nicolas Buchon, Praveen Sethupathy
Published 2020-01-01