Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.

by Zachary D Nagel, Andrew A Beharry, Patrizia Mazzucato, Gaspar J Kitange, Jann N Sarkaria, Eric T Kool, Leona D Samson
Published 2019-01-01

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

by Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria, Nhan L. Tran
Published 2019-11-01

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

by Shiv K. Gupta, Emily J. Smith, Ann C. Mladek, Shulan Tian, Paul A. Decker, Sani H. Kizilbash, Gaspar J. Kitange, Jann N. Sarkaria
Published 2019-01-01

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

by Xiaoyue Chen, Minjie Zhang, Haiyun Gan, Heping Wang, Jeong-Heon Lee, Dong Fang, Gaspar J. Kitange, Lihong He, Zeng Hu, Ian F. Parney, Fredric B. Meyer, Caterina Giannini, Jann N. Sarkaria, Zhiguo Zhang
Published 2018-07-01

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

by Gaspar J. Kitange, Ann C. Mladek, Mark A. Schroeder, Jenny C. Pokorny, Brett L. Carlson, Yuji Zhang, Asha A. Nair, Jeong-Heon Lee, Huihuang Yan, Paul A. Decker, Zhiguo Zhang, Jann N. Sarkaria
Published 2016-03-01