Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

by Hiroko Ono, Atsushi Nakamura, Tomoe Kanbara, Kazuhisa Minami, Shunji Shinohara, Gaku Sakaguchi, Toshiyuki Kanemasa
Published 2014-01-01

Suppression of the acute upregulation of phosphorylated-extracellular regulated kinase in ventral tegmental area by a μ-opioid receptor agonist is related to resistance to rewardin...

by Atsushi Nakamura, Hiroko Ono, Azusa Ando, Mikie Hinata, Kazuki Niidome, Shigeki Omachi, Gaku Sakaguchi, Shunji Shinohara
Published 2017-01-01

The Contribution of Gi/o Protein to Opioid Antinociception in an Oxaliplatin-Induced Neuropathy Rat Model

by Tomoe Kanbara, Atsushi Nakamura, Keiko Takasu, Koichi Ogawa, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Minoru Hasegawa, Gaku Sakaguchi, Toshiyuki Kanemasa
Published 2014-04-01

Establishment of Opioid-Induced Rewarding Effects Under Oxaliplatin-and Paclitaxel-Induced Neuropathy in Rats

by Tomohisa Mori, Tomoe Kanbara, Masato Harumiya, Yoshiyuki Iwase, Aki Masumoto, Sachiko Komiya, Atsushi Nakamura, Masahiro Shibasaki, Toshiyuki Kanemasa, Gaku Sakaguchi, Tsutomu Suzuki
Published 2014-01-01

Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.

by Akihiro Fujikawa, Yukihiro Noda, Hideko Yamamoto, Naomi Tanga, Gaku Sakaguchi, Satoko Hattori, Wen-Jie Song, Ichiro Sora, Toshitaka Nabeshima, Goro Katsuura, Masaharu Noda
Published 2019-01-01

Amyloid β protein impairs motor function via thromboxane A2 in the rat striatum

by Tatsurou Yagami, Yukio Takahara, Chiyomi Ishibashi, Gaku Sakaguchi, Naohiro Itoh, Keiichi Ueda, Hitoshi Nakazato, Noboru Okamura, Yoshiharu Hiramatsu, Tsunetoshi Honma, Akinori Arimura, Toshiyuki Sakaeda, Goro Katsuura
Published 2004-08-01

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase

by Shinji Tagami, Kanta Yanagida, Takashi S. Kodama, Mako Takami, Naoki Mizuta, Hiroshi Oyama, Kouhei Nishitomi, Yu-wen Chiu, Toru Okamoto, Takeshi Ikeuchi, Gaku Sakaguchi, Takashi Kudo, Yoshiharu Matsuura, Akio Fukumori, Masatoshi Takeda, Yasuo Ihara, Masayasu Okochi
Published 2017-10-01