Recent Advances in p53

by Gabriella D’Orazi
Published 2021-02-01

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression

by Gabriella D’Orazi, Mara Cirone
Published 2019-05-01

Nobel committee honors tumor immunologists

by Anand Rotte, Gabriella D’Orazi, Madhuri Bhandaru
Published 2018-10-01

Targeting hypoxia in tumor: a new promising therapeutic strategy

by Maria Carla Bosco, Gabriella D’Orazi, Donatella Del Bufalo
Published 2020-01-01

Correction to: Targeting hypoxia in tumor: a new promising therapeutic strategy

by Maria Carla Bosco, Gabriella D’. Orazi, Donatella Del Bufalo
Published 2020-02-01

Targeting mutant p53 in cancer: the latest insights

by Silvia Di Agostino, Giulia Fontemaggi, Sabrina Strano, Giovanni Blandino, Gabriella D’Orazi
Published 2019-07-01

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

by Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone, Gabriella D’Orazi
Published 2017-09-01

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.

by Lavinia Nardinocchi, Rosa Puca, Ada Sacchi, Gideon Rechavi, David Givol, Gabriella D'Orazi
Published 2009-08-01

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

by Maria Anele Romeo, Maria Anele Romeo, Maria Saveria Gilardini Montani, Maria Saveria Gilardini Montani, Rossella Benedetti, Rossella Benedetti, Roberta Santarelli, Roberta Santarelli, Gabriella D'Orazi, Gabriella D'Orazi, Mara Cirone, Mara Cirone
Published 2020-07-01

Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation

by Alessia Garufi, Giulia Federici, Maria Saveria Gilardini Montani, Alessandra Crispini, Mara Cirone, Gabriella D’Orazi
Published 2020-03-01

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

by Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni, Gabriella D’Orazi
Published 2019-06-01

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

by Marisa Granato, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Published 2017-11-01

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1

by Marisa Granato, Maria Saveria Gilardini Montani, Camilla Angiolillo, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Published 2018-12-01

p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53

by Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Andrea Arena, Gabriella D’Orazi, Mara Cirone
Published 2021-02-01

PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulatin...

by Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Alessia Garufi, Gabriella D’Orazi, Mara Cirone
Published 2020-04-01

P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)–Curcumin Complex

by Alessia Garufi, Eugenia Giorno, Maria Saveria Gilardini Montani, Giuseppa Pistritto, Alessandra Crispini, Mara Cirone, Gabriella D'Orazi
Published 2021-02-01

Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.

by Alessia Garufi, Giuseppa Pistritto, Claudia Ceci, Livia Di Renzo, Roberta Santarelli, Alberto Faggioni, Mara Cirone, Gabriella D'Orazi
Published 2012-01-01

Role of UPR Sensor Activation in Cell Death–Survival Decision of Colon Cancer Cells Stressed by DPE Treatment

by Rossella Benedetti, Maria Saveria Gilardini Montani, Maria Anele Romeo, Andrea Arena, Roberta Santarelli, Gabriella D’Orazi, Mara Cirone
Published 2021-09-01

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival.

by Cristina Lanni, Lavinia Nardinocchi, Rosa Puca, Serena Stanga, Daniela Uberti, Maurizio Memo, Stefano Govoni, Gabriella D'Orazi, Marco Racchi
Published 2010-04-01

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

by Maria Saveria Gilardini Montani, Nives Cecere, Marisa Granato, Maria Anele Romeo, Luca Falcinelli, Umberto Ciciarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Published 2019-05-01