The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells.

by Antoine Guyon, Joël Rousseau, Gabriel Lamothe, Jacques P Tremblay
Published 2020-01-01

Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro

by Antoine Guyon, Joël Rousseau, Francis-Gabriel Bégin, Tom Bertin, Gabriel Lamothe, Jacques P. Tremblay
Published 2021-06-01