A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies.

by Boris Shulgin, Gabriel Helmlinger, Yuri Kosinsky
Published 2016-01-01

A mechanistic tumor penetration model to guide antibody drug conjugate design.

by Christina Vasalou, Gabriel Helmlinger, Bruce Gomes
Published 2015-01-01

Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

by Veronika Voronova, Kirill Zhudenkov, Gabriel Helmlinger, Kirill Peskov
Published 2017-01-01

Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study

by Ivan Azarov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Yuri Kosinsky
Published 2019-06-01

Quantification of Scheduling Impact on Safety and Efficacy Outcomes of Brain Metastasis Radio- and Immuno-Therapies: A Systematic Review and Meta-Analysis

by Veronika Voronova, Svetlana Lebedeva, Marina Sekacheva, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov
Published 2020-09-01

Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology

by Kirill Peskov, Kirill Peskov, Ivan Azarov, Lulu Chu, Veronika Voronova, Yuri Kosinsky, Gabriel Helmlinger
Published 2019-04-01

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human BeingsSummary

by Veronika Voronova, Victor Sokolov, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin
Published 2020-01-01

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia[S]

by Victor Sokolov, Gabriel Helmlinger, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Eva Hurt-Camejo, Rasmus Jansson-Löfmark
Published 2019-09-01

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

by Yuri Kosinsky, Simon J. Dovedi, Kirill Peskov, Veronika Voronova, Lulu Chu, Helen Tomkinson, Nidal Al-Huniti, Donald R. Stanski, Gabriel Helmlinger
Published 2018-02-01

Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling

by Victor Sokolov, Tatiana Yakovleva, Lulu Chu, Weifeng Tang, Peter J. Greasley, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton, Robert C. Penland
Published 2020-04-01

Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysis

by Boris Shulgin, Yuri Kosinsky, Andrey Omelchenko, Lulu Chu, Ganesh Mugundu, Sergey Aksenov, Rodrigo Pimentel, Garrett DeYulia, Geoffrey Kim, Kirill Peskov, Gabriel Helmlinger
Published 2020-01-01

Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model

by Veronika Voronova, Kirill Peskov, Kirill Peskov, Yuri Kosinsky, Gabriel Helmlinger, Lulu Chu, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Wenlin Shao, Rakesh Kumar, Gayle Pouliot, Melinda Merchant, Holly Kimko, Ganesh Mugundu
Published 2021-03-01

Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

by Gabriel Helmlinger, Victor Sokolov, Kirill Peskov, Karen M. Hallow, Yuri Kosinsky, Veronika Voronova, Lulu Chu, Tatiana Yakovleva, Ivan Azarov, Daniel Kaschek, Artem Dolgun, Henning Schmidt, David W. Boulton, Robert C. Penland
Published 2019-06-01