Inflammatory Cytokine Tumor Necrosis Factor α Confers Precancerous Phenotype in an Organoid Model of Normal Human Ovarian Surface Epithelial Cells

by Joseph Kwong, Franky Leung Chan, Kwong-kwok Wong, Michael J. Birrer, Kyra M. Archibald, Frances R. Balkwill, Ross S. Berkowitz, Samuel C. Mok
Published 2009-06-01

Airway dendritic cell maturation in children exposed to air pollution.

by Abigail L Whitehouse, Naseem Mushtaq, Lisa Miyashita, Benjamin Barratt, Ameerah Khan, Harpal Kalsi, Lee Koh, Michele G Padovan, Rossa Brugha, Frances R Balkwill, Andrew J Stagg, Jonathan Grigg
Published 2020-01-01

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

by Robin M. Delaine-Smith, Eleni Maniati, Beatrice Malacrida, Sam Nichols, Reza Roozitalab, Roanne R. Jones, Laura S.M. Lecker, Oliver M.T. Pearce, Martin M. Knight, Frances R. Balkwill
Published 2021-06-01

Discrepancies in the Tumor Microenvironment of Spontaneous and Orthotopic Murine Models of Pancreatic Cancer Uncover a New Immunostimulatory Phenotype for B Cells

by Sarah Spear, Juliana B. Candido, Jacqueline R. McDermott, Jacqueline R. McDermott, Cristina Ghirelli, Eleni Maniati, Stephen A. Beers, Frances R. Balkwill, Hemant M. Kocher, Melania Capasso, Melania Capasso
Published 2019-03-01

A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion

by Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M.T. Pearce
Published 2021-06-01

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

by Eleni Maniati, Chiara Berlato, Ganga Gopinathan, Owen Heath, Panoraia Kotantaki, Anissa Lakhani, Jacqueline McDermott, Colin Pegrum, Robin M. Delaine-Smith, Oliver M.T. Pearce, Priyanka Hirani, Joash D. Joy, Ludmila Szabova, Ruth Perets, Owen J. Sansom, Ronny Drapkin, Peter Bailey, Frances R. Balkwill
Published 2020-01-01

Cancer associated fibroblast FAK regulates malignant cell metabolism

by Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Published 2020-03-01

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

by Juliana B. Candido, Jennifer P. Morton, Peter Bailey, Andrew D. Campbell, Saadia A. Karim, Thomas Jamieson, Laura Lapienyte, Aarthi Gopinathan, William Clark, Ewan J. McGhee, Jun Wang, Monica Escorcio-Correia, Raphael Zollinger, Rozita Roshani, Lisa Drew, Loveena Rishi, Rebecca Arkell, T.R. Jeffry Evans, Colin Nixon, Duncan I. Jodrell, Robert W. Wilkinson, Andrew V. Biankin, Simon T. Barry, Frances R. Balkwill, Owen J. Sansom
Published 2018-05-01