Amikacin Anti-solvents Article Bacterial infections Core shell Dimethylsulphoxides Drug delivery Drug load Janus kinase 2 Janus kinase 3 Mean diameter Nanocarriers One-pot synthesis Particle size analysis Shells (structures) Silica Silica shell Silicon Sols Spectroscopic analysis Synthesis (chemical) X ray powder diffraction computer analysis cross validation decision tree drug potency drug selectivity dual specificity tyrosine phosphorylation regulated kinase 1A dual specificity tyrosine phosphorylation regulated kinase 1B dual specificity tyrosine phosphorylation regulated kinase 2