Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

by Punit P Seth, Ali Jazayeri, Jeff Yu, Charles R Allerson, Balkrishen Bhat, Eric E Swayze
Published 2012-01-01

S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate

by Mehran Nikan, Wenyu Li, Garth A. Kinberger, Punit P. Seth, Eric E. Swayze, Thazha P. Prakash
Published 2019-01-01

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

by Michael E. Østergaard, Josh Nichols, Timothy A. Dwight, Walt Lima, Michael E. Jung, Eric E. Swayze, Punit P. Seth
Published 2017-06-01

A modular analysis of microglia gene expression, insights into the aged phenotype

by Christine E. Cho, Sagar S. Damle, Edward V. Wancewicz, Swagatam Mukhopadhyay, Christopher E. Hart, Curt Mazur, Eric E. Swayze, Fredrik Kamme
Published 2019-02-01

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

by Hien Tran Zhao, Neena John, Vedad Delic, Karli Ikeda-Lee, Aneeza Kim, Andreas Weihofen, Eric E. Swayze, Holly B. Kordasiewicz, Andrew B. West, Laura A. Volpicelli-Daley
Published 2017-09-01

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

by Hien Tran Zhao, Neena John, Vedad Delic, Karli Ikeda-Lee, Aneeza Kim, Andreas Weihofen, Eric E. Swayze, Holly B. Kordasiewicz, Andrew B. West, Laura A. Volpicelli-Daley
Published 2021-09-01

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

by Hien Tran Zhao, Neena John, Vedad Delic, Karli Ikeda-Lee, Aneeza Kim, Andreas Weihofen, Eric E. Swayze, Holly B. Kordasiewicz, Andrew B. West, Laura A. Volpicelli-Daley
Published 2021-06-01

Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice

by Rosie Z Yu, Mark J Graham, Noah Post, Stan Riney, Thomas Zanardi, Shannon Hall, Jennifer Burkey, Colby S Shemesh, Thazha P Prakash, Punit P Seth, Eric E Swayze, Richard S Geary, Yanfeng Wang, Scott Henry
Published 2016-01-01

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

by Colby S Shemesh, Rosie Z Yu, Hans J Gaus, Sarah Greenlee, Noah Post, Karsten Schmidt, Michael T Migawa, Punit P Seth, Thomas A Zanardi, Thazha P Prakash, Eric E Swayze, Scott P Henry, Yanfeng Wang
Published 2016-01-01

Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

by Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze, Ajay Verma
Published 2020-08-01

An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement

by Shane G. Poplawski, Krassimira A. Garbett, Rebekah L. McMahan, Holly B. Kordasiewicz, Hien Zhao, Andrew J. Kennedy, Slavina B. Goleva, Teresa H. Sanders, S. Timothy Motley, Eric E. Swayze, David J. Ecker, J. David Sweatt, Todd P. Michael, Celeste B. Greer
Published 2020-03-01

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.

by Niels H Skotte, Amber L Southwell, Michael E Østergaard, Jeffrey B Carroll, Simon C Warby, Crystal N Doty, Eugenia Petoukhov, Kuljeet Vaid, Holly Kordasiewicz, Andrew T Watt, Susan M Freier, Gene Hung, Punit P Seth, C Frank Bennett, Eric E Swayze, Michael R Hayden
Published 2014-01-01

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

by Andrew J. Kennedy, Elizabeth J. Rahn, Brynna S. Paulukaitis, Katherine E. Savell, Holly B. Kordasiewicz, Jing Wang, John W. Lewis, Jessica Posey, Sarah K. Strange, Mikael C. Guzman-Karlsson, Scott E. Phillips, Kyle Decker, S. Timothy Motley, Eric E. Swayze, David J. Ecker, Todd P. Michael, Jeremy J. Day, J. David Sweatt
Published 2016-09-01

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease

by Tracy A. Cole, Hien Zhao, Timothy J. Collier, Ivette Sandoval, Caryl E. Sortwell, Kathy Steece-Collier, Brian F. Daley, Alix Booms, Jack Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle Graham, Andreas Weihofen, Stephanie Celano, Emily Schulz, Allyson Cole-Strauss, Esteban Luna, Duc Quach, Apoorva Mohan, C. Frank Bennett, Eric E. Swayze, Holly B. Kordasiewicz, Kelvin C. Luk, Katrina L. Paumier
Published 2021-03-01