Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

by Ehrlich Michelle E, Small Scott A, Gatson Joshua W, Lane Rachel F, Gandy Sam
Published 2010-12-01

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels <it>in vitro </it>and <it>in vivo</it>

by Sano Mary, Hyslop Peter, Fraser Paul, Westaway David, Restivo Jessica L, Verges Deborah K, Cirrito John R, Kim Soong H, Steele John W, Bezprozvanny Ilya, Ehrlich Michelle E, Holtzman David M, Gandy Sam
Published 2009-12-01

Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology

by Buxbaum Joseph D, Martins Ralph N, Hyslop Peter, Westaway David, Fraser Paul, Ho Lap, Schmeidler James, Brautigam Hannah, Thomas Carlos, Pedrini Steve, Pasinetti Giulio M, Dickstein Dara L, Hof Patrick R, Ehrlich Michelle E, Gandy Sam
Published 2009-10-01