Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry

by Edward E. Large, Mark A. Silveria, Grant M. Zane, Onellah Weerakoon, Michael S. Chapman
Published 2021-07-01

The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors

by Mark A. Silveria, Edward E. Large, Grant M. Zane, Tommi A. White, Michael S. Chapman
Published 2020-11-01

Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains.

by Edward E Large, Raghavendra Padmanabhan, Kathie L Watkins, Richard F Campbell, Wen Xu, Patrick T McGrath
Published 2017-05-01

Changes to social feeding behaviors are not sufficient for fitness gains of the Caenorhabditis elegans N2 reference strain

by Yuehui Zhao, Lijiang Long, Wen Xu, Richard F Campbell, Edward E Large, Joshua S Greene, Patrick T McGrath
Published 2018-10-01

Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans.

by Edward E Large, Wen Xu, Yuehui Zhao, Shannon C Brady, Lijiang Long, Rebecca A Butcher, Erik C Andersen, Patrick T McGrath
Published 2016-07-01