Editorial: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads

by Dimitrios C. Mastellos, Edimara S. Reis, John D. Lambris
Published 2020-01-01

The evolution and appearance of C3 duplications in fish originate an exclusive teleost c3 gene form with anti-inflammatory activity.

by Gabriel Forn-Cuní, Edimara S Reis, Sonia Dios, David Posada, John D Lambris, Antonio Figueras, Beatriz Novoa
Published 2014-01-01

Complement-Dependent Mechanisms and Interventions in Periodontal Disease

by George Hajishengallis, Tetsuhiro Kajikawa, Evlambia Hajishengallis, Tomoki Maekawa, Edimara S. Reis, Dimitrios C. Mastellos, Despina Yancopoulou, Hatice Hasturk, John D. Lambris
Published 2019-03-01

Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates

by Tetsuhiro Kajikawa, Ruel A. Briones, Ranillo R.G. Resuello, Joel V. Tuplano, Edimara S. Reis, Evlambia Hajishengallis, Cristina A.G. Garcia, Despina Yancopoulou, John D. Lambris, George Hajishengallis
Published 2017-09-01

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

by Andrea Facciabene, Francesco De Sanctis, Stefano Pierini, Edimara S. Reis, Klara Balint, John Facciponte, Jens Rueter, Masahiro Kagabu, Paola Magotti, Evripidis Lanitis, Robert A. DeAngelis, Ronald J. Buckanovich, Wenchao C. Song, John D. Lambris, George Coukos
Published 2017-09-01

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

by Robin Schmitz, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, John S. Yi, Sanjay Khandelwal, Gowthami M. Arepally, Alton B. Farris, Edimara S. Reis, John D. Lambris, Jean Kwun, Stuart J. Knechtle
Published 2021-09-01