Alzheimer disease Alzheimer’s disease Antioxidant activity Article Box-Behnken Juice yield Polyphenolic content Protein content aged caudal middle frontal cortexc cingulate gyrus clinical article clinical assessment controlled study cortical thickness cortical thickness (brain) dentate gyrus molecular layer female gray matter volume hippocampal CA1 region hippocampal CA3 region human imaging lateral occipital cortex lateral orbitofrontal cortex left hemisphere left rostral middle frontal cortex male medial frontal cortex medial orbitofrontal cortex