Adaptive evolution Adaptive methods Brazil COVID-19 Cobalt alloys Diseases Dynamic features Genes Genetic engineering Genome sequences Genome, Viral Genomic analysis Humans India Infectious pathogens Mutation Next-generation sequencing Pathogen analysis pipeline Phylogenetic clade analysis Phylogeny Prediction accuracy Proof of principles SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 South Africa Viruses article cladistics controlled study high throughput sequencing