Functional amyloidogenesis and cytotoxicity-insights into biology and pathology.

by Douglas M Fowler, Jeffery W Kelly
Published 2012-01-01

Keeping up with the genomes: scaling genomic variant interpretation

by Heidi L. Rehm, Douglas M. Fowler
Published 2019-12-01

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

by John Z Chen, Douglas M Fowler, Nobuhiko Tokuriki
Published 2020-06-01

Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis.

by Ting-Wei Mu, Douglas M Fowler, Jeffery W Kelly
Published 2008-02-01

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations

by Ann K. Daly, Allan E. Rettie, Douglas M. Fowler, John O. Miners
Published 2017-12-01

Functional amyloid formation within mammalian tissue.

by Douglas M Fowler, Atanas V Koulov, Christelle Alory-Jost, Michael S Marks, William E Balch, Jeffery W Kelly
Published 2006-01-01

A statistical framework for analyzing deep mutational scanning data

by Alan F. Rubin, Hannah Gelman, Nathan Lucas, Sandra M. Bajjalieh, Anthony T. Papenfuss, Terence P. Speed, Douglas M. Fowler
Published 2017-08-01

Correction to: A statistical framework for analyzing deep mutational scanning data

by Alan F. Rubin, Hannah Gelman, Nathan Lucas, Sandra M. Bajjalieh, Anthony T. Papenfuss, Terence P. Speed, Douglas M. Fowler
Published 2018-02-01

Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning

by Vanessa E. Gray, Katherine Sitko, Floriane Z. Ngako Kameni, Miriam Williamson, Jason J. Stephany, Nicholas Hasle, Douglas M. Fowler
Published 2019-11-01

MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect

by Daniel Esposito, Jochen Weile, Jay Shendure, Lea M. Starita, Anthony T. Papenfuss, Frederick P. Roth, Douglas M. Fowler, Alan F. Rubin
Published 2019-11-01

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

by John C. Rose, Nicholas A. Popp, Christopher D. Richardson, Jason J. Stephany, Julie Mathieu, Cindy T. Wei, Jacob E. Corn, Dustin J. Maly, Douglas M. Fowler
Published 2020-06-01

High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

by Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat Jr., Cole Trapnell, Emily M Hatch, Douglas M Fowler
Published 2020-06-01

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

by Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler
Published 2020-09-01

Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation

by Hannah Gelman, Jennifer N. Dines, Jonathan Berg, Alice H. Berger, Sarah Brnich, Fuki M. Hisama, Richard G. James, Alan F. Rubin, Jay Shendure, Brian Shirts, Douglas M. Fowler, Lea M. Starita, On behalf of the Brotman Baty Institute Mutational Scanning Working Group
Published 2019-12-01

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

by Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl
Published 2020-01-01