Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression.

by Jennifer H R Kenty, Douglas A Melton
Published 2015-01-01

Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration

by Stephanie L Tsai, Clara Baselga-Garriga, Douglas A Melton
Published 2020-01-01

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

by Edwin A. Rosado-Olivieri, Kendall Anderson, Jennifer H. Kenty, Douglas A. Melton
Published 2019-04-01

Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny

by Dario Gerace, Kyle R. Boulanger, Jennifer Hyoje-Ryu Kenty, Douglas A. Melton
Published 2021-05-01

MARIS: method for analyzing RNA following intracellular sorting.

by Siniša Hrvatin, Francis Deng, Charles W O'Donnell, David K Gifford, Douglas A Melton
Published 2014-01-01

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

by Weida Li, Mio Nakanishi, Adrian Zumsteg, Matthew Shear, Christopher Wright, Douglas A Melton, Qiao Zhou
Published 2014-04-01

Correction: Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes

by Jeffrey R. Millman, Chunhui Xie, Alana Van Dervort, Mads Gürtler, Felicia W. Pagliuca, Douglas A. Melton
Published 2016-08-01

Generation of stem cell-derived β-cells from patients with type 1 diabetes

by Jeffrey R. Millman, Chunhui Xie, Alana Van Dervort, Mads Gürtler, Felicia W. Pagliuca, Douglas A. Melton
Published 2016-05-01

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

by Dylan Kotliar, Adrian Veres, M Aurel Nagy, Shervin Tabrizi, Eran Hodis, Douglas A Melton, Pardis C Sabeti
Published 2019-07-01

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

by Nayara C. Leite, Elad Sintov, Torsten B. Meissner, Michael A. Brehm, Dale L. Greiner, David M. Harlan, Douglas A. Melton
Published 2020-07-01

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

by Nadav Sharon, Jordan Vanderhooft, Juerg Straubhaar, Jonas Mueller, Raghav Chawla, Quan Zhou, Elise N. Engquist, Cole Trapnell, David K. Gifford, Douglas A. Melton
Published 2019-05-01

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

by Barak Blum, Adam N Roose, Ornella Barrandon, René Maehr, Anthony C Arvanites, Lance S Davidow, Jeffrey C Davis, Quinn P Peterson, Lee L Rubin, Douglas A Melton
Published 2014-09-01

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

by Aaron R Cox, Ornella Barrandon, Erica P Cai, Jacqueline S Rios, Julia Chavez, Claire W Bonnyman, Carol J Lam, Peng Yi, Douglas A Melton, Jake A Kushner
Published 2016-01-01

A method for the generation of human stem cell-derived alpha cells

by Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton
Published 2020-05-01

Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.

by Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Published 2018-01-01