Article alginic acid controlled study drug delivery system drug release encapsulation Administration, Oral Alginate beads Alginates Animals Anti-Inflammatory Agents Disease Models, Animal Drug Compounding Drug Delivery Systems Electrohydrodynamic Emulsion Excipients Factorial design GIT distribution Hydrodynamics Hydrogen-Ion Concentration Immediate release Irritable Bowel Syndrome Lecithins Loperamide Male Microencapsulation Microspheres Molecular Structure Paracetamol