Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation

by Emma I. Kane, Donald E. Spratt
Published 2021-01-01

Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

by Donald E Spratt, Pascal Mercier, Gary S Shaw
Published 2013-01-01

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response

by Nicholas A. Mathieu, Rafael H. Levin, Donald E. Spratt
Published 2021-03-01

Intersection of Redox Chemistry and Ubiquitylation: Post-Translational Modifications Required for Maintaining Cellular Homeostasis and Neuroprotection

by Emma I. Kane, Kelly L. Waters, Donald E. Spratt
Published 2021-08-01

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response

by Nicholas A. Mathieu, Ermela Paparisto, Stephen D. Barr, Donald E. Spratt
Published 2021-06-01

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity.

by Steven A Beasley, Chloe E Kellum, Rachel J Orlomoski, Feston Idrizi, Donald E Spratt
Published 2020-01-01

Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42

by Claire A. Krasinski, Valerie A. Ivancic, Qiuchen Zheng, Donald E. Spratt, Noel D. Lazo
Published 2018-10-01

Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

by Qiuchen Zheng, Micheal T. Kebede, Bethany Lee, Claire A. Krasinski, Saadman Islam, Liliana A. Wurfl, Merc M. Kemeh, Valerie A. Ivancic, Charles E. Jakobsche, Donald E. Spratt, Noel D. Lazo
Published 2021-08-01