Differential roles of Aβ processing in hypoxia-induced axonal damage

by Melissa G. Christianson, Donald C. Lo
Published 2015-05-01

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.

by Amber L Southwell, Charles W Bugg, Linda S Kaltenbach, Denise Dunn, Stefanie Butland, Andreas Weiss, Paolo Paganetti, Donald C Lo, Paul H Patterson
Published 2011-01-01

Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats

by Zhiquan Zhang, Qing Ma, Bijal Shah, G. Burkhard Mackensen, Donald C. Lo, Joseph P. Mathew, Mihai V. Podgoreanu, Niccolò Terrando, Niccolò Terrando
Published 2017-08-01

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

by Koning Shen, Barbara Calamini, Jonathan A Fauerbach, Boxue Ma, Sarah H Shahmoradian, Ivana L Serrano Lachapel, Wah Chiu, Donald C Lo, Judith Frydman
Published 2016-10-01

Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.

by Sehoon Keum, Han Kyu Lee, Pei-Lun Chu, Matthew J Kan, Min-Nung Huang, Carol J Gallione, Michael D Gunn, Donald C Lo, Douglas A Marchuk
Published 2013-01-01

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

by Leila Pirhaji, Pamela Milani, Simona Dalin, Brook T. Wassie, Denise E. Dunn, Robert J. Fenster, Julian Avila-Pacheco, Paul Greengard, Clary B. Clish, Myriam Heiman, Donald C. Lo, Ernest Fraenkel
Published 2017-09-01

Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay

by Peter H. Reinhart, Linda S. Kaltenbach, Christian Essrich, Denise E. Dunn, Joshua A. Eudailey, C. Todd DeMarco, Gregory J. Turmel, Jennifer C. Whaley, Andrew Wood, Seongeun Cho, Donald C. Lo
Published 2011-07-01

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

by Steven P. Braithwaite, Ralf S. Schmid, Dong Ning He, Mei-Li A. Sung, Seongeon Cho, Lynn Resnick, Michael M. Monaghan, Warren D. Hirst, Christian Essrich, Peter H. Reinhart, Donald C. Lo
Published 2010-09-01

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

by Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Published 2017-02-01

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

by Catherine Z. Chen, Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen, Ruili Huang, Min Shen, Xin Hu, Kelli M. Wilson, Brianna M. Brooks, Hui Guo, Tongan Zhao, Carleen Klump-Thomas, Anton Simeonov, Samuel G. Michael, Donald C. Lo, Matthew D. Hall, Wei Zheng
Published 2021-01-01