Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR

by Elodie Pothin, Dominique Lesuisse, Pierre Lafaye
Published 2020-09-01

Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parki...

by André Malanda, Pierre-Yves Abécassis, Pascal Barnéoud, Pascale Brunel, Véronique Taupin, Xavier Vigé, Dominique Lesuisse
Published 2019-12-01

Non-Human Primate Blood–Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model

by Catarina Chaves, Tuan-Minh Do, Céline Cegarra, Valérie Roudières, Sandrine Tolou, Gilbert Thill, Corinne Rocher, Michel Didier, Dominique Lesuisse
Published 2020-10-01

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

by Tuan-Minh Do, Cécile Capdevila, Laurent Pradier, Véronique Blanchard, Mati Lopez-Grancha, Nathalie Schussler, Anke Steinmetz, Jochen Beninga, Denis Boulay, Philippe Dugay, Patrick Verdier, Nadine Aubin, Gihad Dargazanli, Catarina Chaves, Elisabeth Genet, Yves Lossouarn, Christophe Loux, François Michoux, Nicolas Moindrot, Franck Chanut, Thierry Gury, Stéphanie Eyquem, Delphine Valente, Olivier Bergis, Ercole Rao, Dominique Lesuisse
Published 2020-12-01